@article{fdi:010077691,
  title = {{P}otential of fascaplysin and palauolide from {F}ascaplysinopsis cf reticulata to reduce the risk of bacterial infection in fish farming},
  author = {{M}ai, {T}. and {T}oullec, {J}. and {V}an {W}ynsberge, {S}. and {B}esson, {M}. and {S}oulet, {S}. and {P}etek, {S}ylvain and {A}liotti, {E}. and {E}kins, {M}. and {H}all, {K}. and {E}rpenbeck, {D}. and {L}ecchini, {D}. and {B}eniddir, {M}.{A}. and {S}aulnier, {D}. and {D}ebitus, {C}{\'e}cile},
  editor = {},
  language = {{ENG}},
  abstract = {{M}arine natural products isolated from the sponge {F}ascaplysinopsis cf reticulata, in {F}rench {P}olynesia, were investigated as an alternative to antibiotics to control pathogens in aquaculture. {T}he overuse of antibiotics in aquaculture is largely considered to be an environmental pollution, because it supports the transfer of antibiotic resistance genes within the aquatic environment. {O}ne environmentally friendly alternative to antibiotics is the use of quorum sensing inhibitors ({QSI}s). {Q}uorum sensing ({QS}) is a regulatory mechanism in bacteria which control virulence factors through the secretion of autoinducers ({AI}s), such as acyl-homoserine lactone ({AHL}) in gram-negative bacteria. {V}ibrio harveyi {QS} is controlled through three parallel pathways: {HAI}-1, {AI}-2, and {CAI}-1. {B}ioassay-guided purification of {F}. cf reticulata extract was conducted on two bacterial species, i.e., {T}enacibaculum maritimum and {V}. harveyi for antibiotic and {QS} inhibition bioactivities. {T}oxicity bioassay of fractions was also evaluated on the freshwater fish {P}oecilia reticulata and the marine fish {A}canthurus triostegus. {C}yclohexanic and dichloromethane fractions of {F}. cf reticulata exhibited {QS} inhibition on {V}. harveyi and antibiotic bioactivities on {V}. harveyi and {T}. maritimum, respectively. {P}alauolide (1) and fascaplysin (2) were purified as major molecules from the cyclohexanic and dichloromethane fractions, respectively. {P}alauolide inhibited {QS} of {V}. harveyi through {HAI}-1 {QS} pathway at 50 µg ml-1 (26 µ{M}), while fascaplysin affected the bacterial growth of {V}. harveyi (50 µg  ml-1) and {T}. maritimum (0.25 µg). {T}he toxicity of fascaplysin-enriched fraction ({FEF}) was evaluated and exhibited a toxic effect against fish at 50 µg  ml-1. {T}his study demonstrated for the first time the {QSI} potential of palauolide (1). {F}uture research may assess the toxicity of both the cyclohexanic fraction of the sponge and palauolide (1) on fish, to confirm their potential as alternative to antibiotics in fish farming.},
  keywords = {{POLYNESIE} {FRANCAISE} ; {PACIFIQUE} ; {TUAMOTU} {GAMBIER}},
  booktitle = {},
  journal = {{F}isheries and {A}quatic {S}ciences},
  volume = {22},
  numero = {},
  pages = {art. no 30 [11 ]},
  ISSN = {2234-1757},
  year = {2019},
  DOI = {10.1186/s41240-019-0145-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077691},
}