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      <title>Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age</title>
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    <abstract>Use of dolutegravir-based first-line antiretroviral therapy (ART) in response to rising levels of pretreatment HIV drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) may be limited, given safety concerns for birth defects in women of child-bearing potential. Pooled data from 11 nationally representative surveys show that NNRTI PDR in women is nearly twice that in men, exceeding 10% in 8 of 11 countries monitored, suggesting the urgent need for a non-NNRTI-based ART regimen in this population.</abstract>
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    <subject authority="local">
      <geographic>AFRIQUE SUBSAHARIENNE</geographic>
      <geographic>AMERIQUE LATINE</geographic>
      <geographic>ASIE DU SUD EST</geographic>
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    <classification authority="local">052</classification>
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      <titleInfo>
        <title>AIDS</title>
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      <part>
        <detail type="volume">
          <number>33</number>
        </detail>
        <detail type="volume">
          <number>11</number>
        </detail>
        <extent unit="pages">
          <list> 1797-1799</list>
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      <originInfo>
        <dateIssued>2019</dateIssued>
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      <identifier type="issn">0269-9370</identifier>
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    <identifier type="uri">https://www.documentation.ird.fr/hor/fdi:010077424</identifier>
    <identifier type="doi">10.1097/qad.0000000000002277</identifier>
    <identifier type="issn">0269-9370</identifier>
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      <recordCreationDate encoding="w3cdtf">2020-02-05</recordCreationDate>
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