Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age AIDS 1797-1799 AFRIQUE SUBSAHARIENNE AMERIQUE LATINE ASIE DU SUD EST 2019 fdi:010077424 ENG AIDS 0269-9370 ISI:000501622800016 11 10.1097/qad.0000000000002277 https://www.documentation.ird.fr/hor/fdi:010077424 https://www.documentation.ird.fr/intranet/publi/2020/01/010077424.pdf 33 Horizon (IRD) Use of dolutegravir-based first-line antiretroviral therapy (ART) in response to rising levels of pretreatment HIV drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) may be limited, given safety concerns for birth defects in women of child-bearing potential. Pooled data from 11 nationally representative surveys show that NNRTI PDR in women is nearly twice that in men, exceeding 10% in 8 of 11 countries monitored, suggesting the urgent need for a non-NNRTI-based ART regimen in this population. 052 ; 050 UR233 Cameroun / Congo / Namibie / Philippines / Ouganda / Zimbabwe