%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Inzaule, S. C.
%A Jordan, M. R.
%A Cournil, Amandine
%A Vitoria, M.
%A Ravasi, G.
%A Cham, F.
%A Le, L. V.
%A Dzangare, J.
%A Hamunime, N.
%A Mutenda, N.
%A Aghokeng Fobang, Avelin
%A Bissek, A.
%A Billong, S.
%A Kaleebu, P.
%A Doherty, M.
%A Bertagnolio, S.
%T Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age
%D 2019
%L fdi:010077424
%G ENG
%J AIDS
%@ 0269-9370
%K AFRIQUE SUBSAHARIENNE ; AMERIQUE LATINE ; ASIE DU SUD EST
%M ISI:000501622800016
%N 11
%P 1797-1799
%R 10.1097/qad.0000000000002277
%U https://www.documentation.ird.fr/hor/fdi:010077424
%> https://www.documentation.ird.fr/intranet/publi/2020/01/010077424.pdf
%V 33
%W Horizon (IRD)
%X Use of dolutegravir-based first-line antiretroviral therapy (ART) in response to rising levels of pretreatment HIV drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) may be limited, given safety concerns for birth defects in women of child-bearing potential. Pooled data from 11 nationally representative surveys show that NNRTI PDR in women is nearly twice that in men, exceeding 10% in 8 of 11 countries monitored, suggesting the urgent need for a non-NNRTI-based ART regimen in this population.
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