@article{fdi:010077404,
  title = {{M}eta-transcriptomic identification of hepatitis {B} virus in cerebrospinal fluid in patients with central nervous system disease},
  author = {{P}ettersson, {J}. {H}. {O}. and {P}iorkowski, {G}. and {M}ayxay, {M}. and {R}attanavong, {S}. and {V}ongsouvath, {M}. and {D}avong, {V}. and {A}lfsnes, {K}. and {E}ldholm, {V}. and {L}amballerie, {X}. de and {H}olmes, {E}. {C}. and {N}ewton, {P}. {N}. and {D}ubot {P}{\'e}r{\`e}s, {A}udrey},
  editor = {},
  language = {{ENG}},
  abstract = {{D}etermining the etiological basis of central nervous system ({CNS}) infections is inherently challenging, primarily due to the multi-etiological nature. {U}sing {RNA} sequencing, we aimed to identify microbes present in cerebrospinal fluid ({CSF}) of two patients suffering {CNS} infection, previously diagnosed with {C}ryptococcus sp. and {S}treptococcus pneumoniae infection, respectively. {A}fter meta-transcriptomic analysis, and confirmation with real-time {PCR}, hepatitis {B} virus ({HBV}) was detected in the {CSF} of two patients diagnosed with {CNS} syndrome. {P}hylogenetic analysis of the partial {HBV} genomes from these patients showed that they belonged to genotypes {B} and {C} and clustered with other viruses of {A}sian origin. {I}n countries with high levels of {HBV} endemicity, the virus is likely to be found in patients diagnosed with {CNS} infections, although whether it contributes to symptoms and pathology, or is simply a coincidental infection, is unknown and merits further investigation.},
  keywords = {{H}epatitis {B} virus ; {RNA} sequencing ; {M}eta-transcriptomics ; {C}erebrospinal fluid ; {E}ncephalitis ; {LAOS}},
  booktitle = {},
  journal = {{D}iagnostic {M}icrobiology and {I}nfectious {D}isease},
  volume = {95},
  numero = {4},
  pages = {art. 114878 [4 ]},
  ISSN = {0732-8893},
  year = {2019},
  DOI = {10.1016/j.diagmicrobio.2019.114878},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077404},
}