@article{fdi:010077387,
  title = {{I}nsecticide resistance mechanisms in {A}nopheles gambiae complex populations from {B}urkina {F}aso, {W}est {A}frica},
  author = {{N}amountougou, {M}. and {S}oma, {D}. {D}. and {K}ientega, {M}. and {B}albone, {M}. and {K}abore, {D}. {P}. {A}. and {D}rabo, {S}. {F}. and {C}oulibaly, {A}. {Y}. and {F}ournet, {F}lorence and {B}aldet, {T}. and {D}iabate, {A}. and {D}abire, {R}. {K}. and {G}nankine, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{V}ector control constitutes a fundamental approach in reducing vector density and the efficient option to break malaria transmission in {A}frica. {M}alaria vectors developed resistance to almost all classes of insecticides recommended by {WHO} for vector control in most places of {A}frican countries and may compromise the vector control strategies. {T}his study updated the resistance status of {A}nopheles gambiae complex populations to insecticides recommended for vector control in the western part of {B}urkina {F}aso. {I}nsecticide susceptibility bioassays were performed on seven natural populations of {A}n. gambiae complex from western {B}urkina {F}aso in the 2016 rainy season using the {WHO} protocol. {B}iochemical assays were carried out according to the {WHO} protocol on the same populations to estimate detoxifying enzymes activities including non-specific esterases ({NSE}s), oxidases (cytochrome {P}450) and {G}lutathione-{S}-{T}ransferases ({GST}s). {P}olymerase {C}hain {R}eactions ({PCR}s) were performed for the identification of the {A}n. gambiae complex species as well as the detection of kdr-west and ace-1 mutations. {S}usceptibility bioassays showed that {A}n. gambiae complex was multi-resistant to pyrethroids, {DDT} and carbamates in almost all areas. {T}he mortality rates ranged from 10 to 38%, 2.67 to 59.57% and 64.38 to 98.02% for {D}eltamethrin, {DDT} and {B}endiocarb respectively. {A} full susceptibility (100%) to an organophosphate, the {C}hlorpyrifos-methyl, was observed at the different sites. {T}hree (3) species of the {A}n. gambiae complex were identified: {A}n. gambiae s.s, {A}n. coluzzii and {A}n. arabiensis. {T}he frequencies of the kdr-w mutation were highly widespread (0.66 to 0.98) among the three species of the complex. {T}he ace-1 mutation was detected at low frequencies (0 to 0.12) in {A}n. gambiae s.s and {A}n. coluzzii. {A} high level of {GST}s and {NSE}s were observed within the different populations of the {A}n. gambiae complex. {S}everal mechanisms of insecticide resistance were found simultaneously in the same populations of {A}n. gambiae complex conferring high multi-resistance to {DDT}, {C}arbamate and {P}yrethroids. {T}he full susceptibility of {A}n. gambiae complex to organophosphates is a useful data for the national malaria control program in selecting the most appropriate products to both maintain the effectiveness of vector control strategies and best manage insecticide resistance as well as developing new alternative strategies for the control of major malaria vectors in {B}urkina {F}aso.},
  keywords = {{M}alaria ; {V}ector control ; {P}yrethroids resistance ; {M}etabolic resistance ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {197},
  numero = {},
  pages = {art. 105054 [9 p.]},
  ISSN = {0001-706{X}},
  year = {2019},
  DOI = {10.1016/j.actatropica.2019.105054},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077387},
}