@article{fdi:010077377,
  title = {{A}rtemisinin bioactivity and resistance in malaria parasites},
  author = {{T}alman, {A}rthur and {C}lain, {J}. and {D}uval, {R}omain and {M}enard, {R}. and {A}riey, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}rtemisinin is the most widely-used compound against malaria and plays a critical role in the treatment of malaria worldwide. {R}esistance to artemisinin emerged about a decade ago in {S}outheast {A}sia and it is paramount to prevent its spread or emergence in {A}frica. {A}rtemisinin has a complex mode of action and can cause widespread injury to many components of the parasite. {I}n this review, we outline the different metabolic pathways affected by artemisinin, including the unfolded protein response, protein polyubiquitination, proteasome, phosphatidylinositol-3-kinase, and the eukaryotic translation initiation factor 2 alpha. {B}ased on recently published data, we present a model of how these different pathways interplay and how mutations in {K}13, the main identified resistance marker, may help parasites survive under artemisinin pressure.},
  keywords = {{ASIE} {DU} {SUD} {EST}},
  booktitle = {},
  journal = {{T}rends in {P}arasitology},
  volume = {35},
  numero = {12},
  pages = {953--963},
  ISSN = {1471-4922},
  year = {2019},
  DOI = {10.1016/j.pt.2019.09.005},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077377},
}