@article{fdi:010077373,
  title = {{C}hanges in monocyte subsets are associated with clinical outcomes in severe malarial anaemia and cerebral malaria},
  author = {{R}oyo, {J}ade and {R}ahabi, {M}. and {K}amaliddin, {C}. and {E}zinmegnon, {S}. and {O}lagnier, {D}. and {A}uthier, {H}. and {M}assougbodji, {A}. and {A}lao, {J}. and {L}adipo, {Y}. and {D}eloron, {P}hilippe and {B}ertin, {G}wladys and {P}ipy, {B}. and {C}oste, {A}. and {A}ubouy, {A}gn{\`e}s},
  editor = {},
  language = {{ENG}},
  abstract = {{M}onocytes are plastic heterogeneous immune cells involved in host-parasite interactions critical for malaria pathogenesis. {H}uman monocytes have been subdivided into three populations based on surface expression of {CD}14 and {CD}16.{W}e hypothesised that proportions and phenotypes of circulating monocyte subsets can be markers of severity or fatality in children with malaria. {T}o address this question, we compared monocytes sampled in children with uncomplicated malaria, severe malarial anaemia, or cerebral malaria. {F}low cytometry was used to distinguish and phenotype monocyte subsets through {CD}14, {CD}16, {CD}36 and {TLR}2 expression. {D}ata were first analysed by univariate analysis to evaluate their link to severity and death. {S}econd, multinomial logistic regression was used to measure the specific effect of monocyte proportions and phenotypes on severity and death, after adjustments for other variables unrelated to monocytes. {M}ultivariate analysis demonstrated that decreased percentages of non-classical monocytes were associated with death, suggesting that this monocyte subset has a role in resolving malaria. {U}sing univariate analysis, we also showed that the role of non-classical monocytes involves a mostly anti-inflammatory profile and the expression of {CD}16. {F}urther studies are needed to decipher the functions of this sub-population during severe malaria episodes, and understand the underlying mechanisms.},
  keywords = {{AFRIQUE}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {9},
  numero = {},
  pages = {art. 17545 [13 p.]},
  ISSN = {2045-2322},
  year = {2019},
  DOI = {10.1038/s41598-019-52579-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077373},
}