So R. T. Y. auteur aut IRD Chu D. K. W. auteur aut IRD Miguel Eve auteur aut IRD Perera Rapm auteur aut IRD Oladipo J. O. auteur aut IRD Fassi-Fihri O. auteur aut IRD Aylet G. auteur aut IRD Ko R. L. W. auteur aut IRD Zhou Z. Q. auteur aut IRD Cheng M. S. auteur aut IRD Kuranga S. A. auteur aut IRD Roger F. L. auteur aut IRD Chevalier V. auteur aut IRD Webby R. J. auteur aut IRD Woo P. C. Y. auteur aut IRD Poon L. L. M. auteur aut IRD Peiris M. auteur aut IRD text journalArticle eng text/pdf born digital access Genetic recombination has frequently been observed in coronaviruses. Here, we sequenced multiple complete genomes of dromedary camel coronavirus HKU23 (DcCoV-HKU23) from Nigeria, Morocco, and Ethiopia and identified several genomic positions indicative of cross-species virus recombination events among other betacoronaviruses of the subgenus Embecovirus (Glade A beta-CoVs). Recombinant fragments of a rabbit coronavirus (RbCoV-HKU14) were identified at the hemagglutinin esterase gene position. Homolog fragments of a rodent CoV were also observed at 8.9-kDa open reading frame 4a at the 3' end of the spike gene. The patterns of recombination differed geographically across the African region, highlighting a mosaic structure of DcCoV-HKU23 genomes circulating in dromedaries. Our results highlighted active recombination of coronaviruses circulating in dromedaries and are also relevant to the emergence and evolution of other betacoronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV). IMPORTANCE Genetic recombination is often demonstrated in coronaviruses and can result in host range expansion or alteration in tissue tropism. Here, we showed interspecies events of recombination of an endemic dromedary camel coronavirus, HKU23, with other Glade A betacoronaviruses. Our results supported the possibility that the zoonotic pathogen MERS-CoV, which also cocirculates in the same camel species, may have undergone similar recombination events facilitating its emergence or may do so in its future evolution. specialized coronaviruses betacoronaviruses recombination phylogeny dromedary camels evolution NIGERIA ETHIOPIE MAROC AFRIQUE DE l'OUEST AFRIQUE DE l'EST AFRIQUE DU NORD 052 080 93 23 e01236-19 [18 p.] 2019 0022-538X https://www.documentation.ird.fr/hor/fdi:010077341 10.1128/jvi.01236-19 0022-538X [F B010077341] https://www.documentation.ird.fr/hor/fdi:010077341 https://www.documentation.ird.fr/intranet/publi/2019/12/010077341.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-01-07 2025-02-24 fdi:010077341 fre