@article{fdi:010077318,
  title = {{T}he {M}odification of the flavonoid naringenin by {B}radyrhizobium sp. strain {ORS}285 changes the nod genes inducer function to a growth stimulator},
  author = {{N}ouwen, {N}ico and {G}argani, {D}. and {G}iraud, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{A}s inducers of nodulation (nod) genes, flavonoids play an important role in the symbiotic interaction between rhizobia and legumes. {H}owever, in addition to the control of expression of nod genes, many other effects of flavonoids on rhizobial cells have been described. {H}ere, we show that the flavonoid naringenin stimulates the growth of the photosynthetic {B}radyrhizobium sp. strain {ORS}285. {T}his growth-stimulating effect was still observed for strain {ORS}285 with nod{D}1, nod{D}2, or the naringenin-degrading fde operon deleted. {P}henotypic microarray analysis indicates that in cells grown in the presence of naringenin, the glycerol and fatty acid metabolism is activated. {M}oreover, electron microscopic and enzymatic analyses show that polyhydroxy alkanoate metabolism is altered in cells grown in the presence of naringenin. {A}lthough strain {ORS}285 was able to degrade naringenin, a fraction was converted into an intensely yellow-colored molecule with an m/z (+) of 363.0716. {F}urther analysis indicates that this molecule is a hydroxylated and {O}-methylated form of naringenin. {I}n contrast to naringenin, this derivative did not induce nod gene expression, but it did stimulate the growth of strain {ORS}285. {W}e hypothesize that the growth stimulation and metabolic changes induced by naringenin are part of a mechanism to facilitate the colonization and infection of naringeninexuding host plants.},
  keywords = {flavonoid ; mutualism ; nodule organogenesis ; rhizobium},
  booktitle = {},
  journal = {{M}olecular {P}lant-{M}icrobe {I}nteractions},
  volume = {32},
  numero = {11},
  pages = {1517--1525},
  ISSN = {0894-0282},
  year = {2019},
  DOI = {10.1094/mpmi-05-19-0133-r},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077318},
}