@article{fdi:010077301,
  title = {{G}enomic analyses of {B}urkholderia cenocepacia reveal multiple species with differential host-adaptation to plants and humans},
  author = {{W}allner, {A}. and {K}ing, {E}. and {N}gonkeu, {E}. {L}. {M}. and {M}oulin, {L}ionel and {B}{\'e}na, {G}illes},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {B}urkholderia cenocepacia is a human opportunistic pathogen causing devastating symptoms in patients suffering from immunodeficiency and cystic fibrosis. {O}ut of the 303 {B}. cenocepacia strains with available genomes, the large majority were isolated from a clinical context. {H}owever, several isolates originate from other environmental sources ranging from aerosols to plant endosphere. {P}lants can represent reservoirs for human infections as some pathogens can survive and sometimes proliferate in the rhizosphere. {W}e therefore investigated if {B}. cenocepacia had the same potential. {R}esults {W}e selected genome sequences from 31 different strains, representative of the diversity of ecological niches of {B}. cenocepacia, and conducted comparative genomic analyses in the aim of finding specific niche or host-related genetic determinants. {P}hylogenetic analyses and whole genome average nucleotide identity suggest that strains, registered as {B}. cenocepacia, belong to at least two different species. {C}ore-genome analyses show that the clade enriched in environmental isolates lacks multiple key virulence factors, which are conserved in the sister clade where most clinical isolates fall, including the highly virulent {ET}12 lineage. {S}imilarly, several plant associated genes display an opposite distribution between the two clades. {F}inally, we suggest that {B}. cenocepacia underwent a host jump from plants/environment to animals, as supported by the phylogenetic analysis. {W}e eventually propose a name for the new species that lacks several genetic traits involved in human virulence. {C}onclusion {R}egardless of the method used, our studies resulted in a disunited perspective of the {B}. cenocepacia species. {S}trains currently affiliated to this taxon belong to at least two distinct species, one having lost several determining animal virulence factors.},
  keywords = {{B}urkholderia cenocepacia ; {O}pportunistic pathogen ; {C}omparative genomics ; {H}ost adaptation ; {PGPR}},
  booktitle = {},
  journal = {{BMC} {G}enomics},
  volume = {20},
  numero = {1},
  pages = {art. 803 [15 p.]},
  ISSN = {1471-2164},
  year = {2019},
  DOI = {10.1186/s12864-019-6186-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077301},
}