Vantaux Amélie auteur aut IRD Hien D. F. de S. auteur aut IRD Yameogo B. auteur aut IRD Thomas F. auteur aut IRD Cohuet Anna auteur aut IRD Lefèvre Thierry auteur aut IRD text journalArticle eng text/pdf reformatted digital access Previous studies have shown that Plasmodium parasites can manipulate mosquito feeding behaviors such as motivation and avidity to feed on vertebrate hosts, in ways that increase the probability of parasite transmission. These studies, however, have been mainly carried out on non-natural and/or laboratory based model systems and hence may not reflect what occurs in the field. We now need to move closer to the natural setting, if we are to fully capture the ecological and evolutionary consequences of these parasite-induced behavioral changes. As part of this effort, we conducted a series of experiments to investigate the long and short-range behavioral responses to human stimuli in the mosquito Anopheles coluzzii during different stages of infection with sympatric field isolates of the human malaria parasite Plasmodium falciparum in Burkina Faso. First, we used a dual-port olfactometer designed to take advantage of the whole body odor to gauge mosquito long-range host-seeking behaviors. Second, we used a locomotor activity monitor system to assess mosquito short-range behaviors. Compared to control uninfected mosquitoes, P. falciparum infection had no significant effect neither on long-range nor on short-range behaviors both at the immature and mature stages. This study, using a natural mosquito-malaria parasite association, indicates that manipulation of vector behavior may not be a general phenomenon. We speculate that the observed contrasting phenotypes with model systems might result from coevolution of the human parasite and its natural vector. Future experiments, using other sympatric malaria mosquito populations or species are required to test this hypothesis. In conclusion, our results highlight the importance of following up discoveries in laboratory model systems with studies on natural parasite-mosquito interactions to accurately predict the epidemiological, ecological and evolutionary consequences of parasite manipulation of vector behaviors. specialized PALUDISME TRANSMISSION VECTEUR AGENT PATHOGENE RELATION HOTE PARASITE COEVOLUTION MODELISATION BURKINA FASO BOBO DIOULASSO 052ANOPAL02 3 art. no 86 [12 ] 2015 2296-701X https://www.documentation.ird.fr/hor/fdi:010077269 10.3389/fevo.2015.00086 2296-701X [F B010077269] https://www.documentation.ird.fr/hor/fdi:010077269 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-01/010077269.pdf IRD - Base Horizon / Pleins textes 2020-01-22 2020-03-09 fdi:010077269 fre