%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Wu, D. S.
%A von Roepenack-Lahaye, E.
%A Buntru, M.
%A de Lange, O.
%A Schandry, N.
%A Perez-Quintero, A. L.
%A Weinberg, Z.
%A Lowe-Power, T. M.
%A Szurek, Boris
%A Michael, A. J.
%A Allen, C.
%A Schillberg, S.
%A Lahaye, T.
%T A plant pathogen type III effector protein subverts translational regulation to boost host polyamine levels
%D 2019
%L fdi:010077209
%G ENG
%J Cell Host and Microbe
%@ 1931-3128
%M ISI:000496264400012
%N 5
%P 638-649+ 5
%R 10.1016/j.chom.2019.09.014
%U https://www.documentation.ird.fr/hor/fdi:010077209
%> https://www.documentation.ird.fr/intranet/publi/2019/11/010077209.pdf
%V 26
%W Horizon (IRD)
%X Pathogenic bacteria inject effector proteins into host cells to manipulate cellular processes and facilitate the infection. Transcription-activator-like effectors (TALEs), an effector class in plant pathogenic bacteria, transcriptionally activate host genes to promote disease. We identify arginine decarboxylase (ADC) genes as the host targets of Brg11, a TALE-like effector from the plant pathogen Ralstonia solanacearum. Brg11 targets a 17-bp sequence that was found to be part of a conserved 50-bp motif, termed the ADC-box, upstream of ADC genes involved in polyamine biosynthesis. The transcribed ADC-box attenuates translation from native ADC mRNAs; however, Brg11 induces truncated ADC mRNAs lacking the ADC-box, thus bypassing this translational control. As a result, Brg11 induces elevated polyamine levels that trigger a defense reaction and likely inhibits bacterial niche competitors but not R. solanacearum. Our findings suggest that Brg11 may give R. solanacearum a competitive advantage and uncover a role for bacterial effectors in regulating ternary microbe-host-microbe interactions.
%$ 076 ; 020