@article{fdi:010077209,
  title = {{A} plant pathogen type {III} effector protein subverts translational regulation to boost host polyamine levels},
  author = {{W}u, {D}. {S}. and von {R}oepenack-{L}ahaye, {E}. and {B}untru, {M}. and de {L}ange, {O}. and {S}chandry, {N}. and {P}erez-{Q}uintero, {A}. {L}. and {W}einberg, {Z}. and {L}owe-{P}ower, {T}. {M}. and {S}zurek, {B}oris and {M}ichael, {A}. {J}. and {A}llen, {C}. and {S}chillberg, {S}. and {L}ahaye, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}athogenic bacteria inject effector proteins into host cells to manipulate cellular processes and facilitate the infection. {T}ranscription-activator-like effectors ({TALE}s), an effector class in plant pathogenic bacteria, transcriptionally activate host genes to promote disease. {W}e identify arginine decarboxylase ({ADC}) genes as the host targets of {B}rg11, a {TALE}-like effector from the plant pathogen {R}alstonia solanacearum. {B}rg11 targets a 17-bp sequence that was found to be part of a conserved 50-bp motif, termed the {ADC}-box, upstream of {ADC} genes involved in polyamine biosynthesis. {T}he transcribed {ADC}-box attenuates translation from native {ADC} m{RNA}s; however, {B}rg11 induces truncated {ADC} m{RNA}s lacking the {ADC}-box, thus bypassing this translational control. {A}s a result, {B}rg11 induces elevated polyamine levels that trigger a defense reaction and likely inhibits bacterial niche competitors but not {R}. solanacearum. {O}ur findings suggest that {B}rg11 may give {R}. solanacearum a competitive advantage and uncover a role for bacterial effectors in regulating ternary microbe-host-microbe interactions.},
  keywords = {},
  booktitle = {},
  journal = {{C}ell {H}ost and {M}icrobe},
  volume = {26},
  numero = {5},
  pages = {638--649+ 5 p.},
  ISSN = {1931-3128},
  year = {2019},
  DOI = {10.1016/j.chom.2019.09.014},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077209},
}