@article{fdi:010077099,
  title = {{VAR}2{CSA} serology to detect {P}lasmodium falciparum transmission patterns in pregnancy},
  author = {{F}onseca, {A}. {M}. and {G}onzalez, {R}. and {B}ardaji, {A}. and {J}airoce, {C}. and {R}uperez, {M}. and {J}imenez, {A}. and {Q}uinto, {L}. and {C}istero, {P}. and {V}ala, {A}. and {S}acoor, {C}. and {G}upta, {H}. and {H}egewisch-{T}aylor, {J}. and {B}rew, {J}. and {T}uikue {N}dam, {N}icaise and {K}ariuki, {S}. and {L}opez, {M}. and {D}obano, {C}. and {C}hitnis, {C}. {E}. and {O}uma, {P}. and {R}amharter, {M}. and {A}bdulla, {S}. and {A}ponte, {J}. {J}. and {M}assougbodji, {A}. and {B}riand, {V}al{\'e}rie and {M}ombo-{N}goma, {G}. and {D}esai, {M}. and {C}ot, {M}ichel and {N}hacolo, {A}. and {S}evene, {E}. and {M}acete, {E}. and {M}enendez, {C}. and {M}ayor, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}regnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. {T}o identify antibody signatures of recent {P}lasmodium falciparum exposure during pregnancy, we dissected {I}g{G} responses against {VAR}2{CSA}, the parasite antigen that mediates placental sequestration. {W}e used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from {M}ozambique, {B}enin, {K}enya, {G}abon, {T}anzania, and {S}pain. {T}wo {VAR}2{CSA} peptides of limited polymorphism were immunogenic and targeted by {I}g{G} responses readily boosted during infection and with estimated half-lives of <2 years. {S}eroprevalence against these peptides reflected declines and rebounds of transmission in southern {M}ozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of {P} falciparum infections. {T}hese data suggest that {VAR}2{CSA} serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.},
  keywords = {{MOZAMBIQUE} ; {BENIN} ; {GABON} ; {KENYA} ; {TANZANIE}},
  booktitle = {},
  journal = {{E}merging {I}nfectious {D}iseases},
  volume = {25},
  numero = {10},
  pages = {1851--1860},
  ISSN = {1080-6040},
  year = {2019},
  DOI = {10.3201/eid2510.181177},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077099},
}