Agbota G. auteur aut IRD Fievet Nadine auteur aut IRD Heude B. auteur aut IRD Accrombessi M. auteur aut IRD Ahouayito U. auteur aut IRD Yovo E. auteur aut IRD Dossa D. auteur aut IRD Dramane L. auteur aut IRD Gartner Agnès auteur aut IRD Ezinmegnon S. auteur aut IRD Marcos J. Y. auteur aut IRD Vachot L. auteur aut IRD Tissieres P. auteur aut IRD Massougbodji A. auteur aut IRD Martin-Prével Yves auteur aut IRD Cot Michel auteur aut IRD Briand Valérie auteur aut IRD text journalArticle eng text/pdf born digital access Background According to the Developmental Origins of Health and Diseases concept, exposures in the preconception period may be critical. For the first time, we evaluated the effect of preconception poor anthropometric status on infant's growth in sub-Saharan Africa. Methods A mother-child cohort was followed prospectively from preconception to 1 year old in Benin. Maternal anthropometric status was assessed by prepregnancy body mass index (BMI), approximated by BMI at the first antenatal visit before 7 weeks' gestation, and gestational weight gain (GWG). BMI was categorized as underweight, normal, overweight, and obesity according to World Health Organization standards. GWG was categorized as low (<7 kg), mild (7-12 kg), and high (>12 kg). In infant, stunting and wasting were defined as length-for-age and weight-for-length z scores less than -2 SD, respectively. We evaluated the association between BMI/GWG and infant's weight and length at birth and during the first year of life, as well as with stunting and wasting at 12 months using mixed linear and logistic regression models. Results In multivariate, preconceptional underweight was associated with a lower infant's weight at birth and during the first year (-164 g; 95% CI, -307 to -22; and -342 g; 95% CI, -624 to -61, respectively) and with a higher risk of stunting at 12 months (adjusted odds ratio [aOR] = 3.98; 95% CI, 1.01-15.85). Furthermore, preconceptional obesity and a high GWG were associated with a higher weight and length at birth and during the first year. Conclusion Underweight and obesity before conception as well as GWG were associated with infant's growth. These results argue for preventive interventions starting as early as the preconception period to support child long-term health. specialized Preconceptional cohort study pregnancy maternal anthropometric status infant growth BENIN 050 054 15 1 e12573 [11 ] 2019 2047-6310 https://www.documentation.ird.fr/hor/fdi:010077090 10.1111/ijpo.12573 2047-6310 [F B010077090] https://www.documentation.ird.fr/hor/fdi:010077090 https://www.documentation.ird.fr/intranet/publi/depot/2020-11-19/010077090.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2019-11-05 2025-02-24 fdi:010077090 fre