Masse S. auteur aut IRD Ayhan Nazli auteur aut IRD Capai L. auteur aut IRD Bosseur F. auteur aut IRD Lamballerie X. de auteur aut IRD Charrel R. auteur aut IRD Falchi A. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Sandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the present study was to investigate the seroprevalence of TOSV and SFSV antibodies in a healthy population from Corsica. In this cross-sectional study, participants were enrolled (i) from a medical staff at the University of Corsica and (ii) from general practitioners of the Corsican Sentinelles Network. The seroprevalence study was based on a virus microneutralization assay. A total of 240 sera were tested. Altogether, 54 sera (22.5%) were confirmed positive for TOSV antibodies, whereas none were positive for SFSV (0/240). The residential district of participants was significantly associated with TOSV seropositivity (p value = 0.005). The rate of the seropositivity against TOSV in our study suggests that the Corsican population is well exposed to the TOSV. These results encourage the implementation of a systematic surveillance system including entomological, microbiological, and medical aspects for the collection of better information on the diseases that are associated with phleboviruses in Corsica and beyond in the regions where these viruses are present. specialized Sandfly Fever Sicilian virus seroprevalence microneutralization meningitis arbovirus arthropod-borne virus Phlebovirus Phenuiviridae Bunyavirales sandfly FRANCE CORSE 052 11 9 art. 817 [8 p.] 2019 https://www.documentation.ird.fr/hor/fdi:010077084 10.3390/v11090817 [F B010077084] https://www.documentation.ird.fr/hor/fdi:010077084 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-10/010077084.pdf IRD - Base Horizon / Pleins textes 2019-11-05 2025-02-24 fdi:010077084 fre