@article{fdi:010077079,
  title = {{M}ayaro virus infects human chondrocytes and induces the expression of arthritis-related genes associated with joint degradation},
  author = {{B}engue, {M}. and {F}erraris, {P}auline and {B}aronti, {C}{\'e}cile and {D}iagne, {C}. {T}. and {T}alignani, {L}. and {W}ichit, {S}. and {L}i{\'e}geois, {F}lorian and {B}isbal, {C}. and {N}ougairede, {A}. and {M}iss{\'e}, {D}oroth{\'e}e},
  editor = {},
  language = {{ENG}},
  abstract = {{M}ayaro virus ({MAYV}) is an emerging arthritogenic alphavirus belonging to the {T}ogaviridae family. {I}nfection leads to a dengue-like illness accompanied by severe polyarthralgia. {H}owever, the molecular and cellular mechanisms of arthritis as a result of {MAYV} infection remain poorly understood. {I}n the present study, we assess the susceptibility of human chondrocytes ({HC}), fibroblast-like synoviocytes and osteoblasts that are the major cell types involved in osteoarthritis, to infection with {MAYV}. {W}e show that these cells are highly permissive to {MAYV} infection and that viral {RNA} copy number and viral titers increase over time in infected cells. {K}nowing that {HC} are the primary cells in articular cartilage and are essential for maintaining the cartilaginous matrix, gene expression studies were conducted in {MAYV}-infected primary {HC} using polymerase chain reaction ({PCR}) arrays. {T}he infection of the latter cells resulted in an induction in the expression of several matrix metalloproteinases ({MMP}) including {MMP}1, {MMP}7, {MMP}8, {MMP}10, {MMP}13, {MMP}14 and {MMP}15 which could be involved in the destruction of articular cartilage. {I}nfected {HC} were also found to express significantly increased levels of various {IFN}-stimulated genes and arthritogenic mediators such as {TNF}-alpha and {IL}-6. {I}n conclusion, {MAYV}-infected primary {HC} overexpress arthritis-related genes, which may contribute to joint degradation and pathogenesis.},
  keywords = {arbovirus ; {M}ayaro virus ; matrix metalloproteinases ; extracellular matrix ; chondrocyte ; synoviocyte ; osteoblast ; innate immunity ; {IL}-6 ; {TNF}-alpha},
  booktitle = {},
  journal = {{V}iruses},
  volume = {11},
  numero = {9},
  pages = {art. 797 [13 ]},
  year = {2019},
  DOI = {10.3390/v11090797},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077079},
}