@article{fdi:010077048,
  title = {{H}elietta apiculata : a tropical weapon against {C}hagas disease},
  author = {{F}erreira, {M}. {E}. and de {A}rias, {A}. {R}. and {Y}aluff, {G}. and de {B}ilbao, {N}. {V}. and {N}akayama, {H}. and {T}orres, {S}. and {S}chinini, {A}. and {T}orresa, {S}. and {S}erna, {E}. and {T}orrecilhas, {A}. {C}. and {F}ournet, {A}lain and {C}ebrian-{T}orrejon, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he present study pretends to evaluate the in vivo efficacy of the crude chloroform bark extract of {H}elietta apiculata, then the activity will be compared with the reference drug, benznidazole, in acute {T}rypanosoma cruzi infected mice when administered by oral route. {T}he chloroformic extract of {H}elieta apiculata was administered by oral route at 5, 10 and 50 mg/kg daily for two weeks. {T}his study has shown a moderate efficacy of the {H}. apiculata bark extract in reducing {T}. cruzi parasitaemia in 42 to 54% after a monitoring of 60 days post-infection and when compared with control groups. {C}oncerning mice mortality, only two only two mice died, one from the control group and the other one from the group threated with 10 mg of the chlorofom extract of {H}. apiculata, suggesting the potential of {H}. apiculta extracts as a safe and inexpensive treatment of {C}hagas disease.},
  keywords = {{H}elietta apiculata ; rutaceae ; chagas disease ; {T}rypanosoma cruzi ; experimental treatment ; {AMERIQUE} {DU} {SUD} ; {PARAGUAY}},
  booktitle = {},
  journal = {{N}atural {P}roduct {R}esearch},
  volume = {33},
  numero = {22},
  pages = {3308--3311},
  ISSN = {1478-6419},
  year = {2019},
  DOI = {10.1080/14786419.2018.1472594},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077048},
}