On hepatocellular carcinoma in South America and early-age onset of the disease

On hepatocellular carcinoma in South America and early-age onset of the disease Pineau P. auteur aut IRD Ruiz E. auteur aut IRD Deharo Eric auteur aut IRD Bertani Stéphane auteur aut IRD text journalArticle eng text/pdf born digital access Hepatocellular carcinoma (HCC) is one of the most predominant tumor types worldwide, being particularly prevalent in sub-Saharan Africa and East Asia. However, HCC is inexplicably underreported in South America, despite unsettling clinical epidemiological trends of the disease on this continent. Here, we review the current knowledge on HCC presentation in Peru. We emphasize the well-documented occurrence of an early-age nosological form of the disease in Andean descent populations. We further discuss the reasons for such HCC clinical presentation, as well as the implications for liver cancer screening, management, and prevention. specialized Liver cancer Cancer risk factor Hepatitis B virus (HBV) Indigenous people Low- and middle-income countries Global health transition PEROU ANDES 050 052 Clinics and Research in Hepatology and Gastroenterology 43 5 522-526 2019 2210-7401 https://www.documentation.ird.fr/hor/fdi:010077041 10.1016/j.clinre.2018.10.019 2210-7401 [F B010077041] https://www.documentation.ird.fr/hor/fdi:010077041 https://www.documentation.ird.fr/intranet/publi/2019/10/010077041.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2019-11-05 2025-02-24 fdi:010077041 fre