Dao M. C. auteur aut IRD Belda E. auteur aut IRD Prifti E. auteur aut IRD Everard A. auteur aut IRD Kayser B. D. auteur aut IRD Bouillot J. L. auteur aut IRD Chevallier J. M. auteur aut IRD Pons N. auteur aut IRD Le Chatelier E. auteur aut IRD Ehrlich S. D. auteur aut IRD Doré J. auteur aut IRD Aron-Wisnewsky J. auteur aut IRD Zucker Jean-Daniel auteur aut IRD Cani P. D. auteur aut IRD Clément K. auteur aut IRD text journalArticle eng text/pdf born digital access The gut bacterial species Akkermansia muciniphila is associated with a healthier clinical profile. The purpose of this study was to determine the association between A. muciniphila and glucose homeostasis in patients undergoing bariatric surgery (BS): gastric banding (GB) or Roux-en-Y gastric bypass (RYGB). This nonrandomized prospective study included 65 women with severe obesity. Longitudinal analysis included subjects for whom A. muciniphila data were available at follow-up [1, 3, and 12 mo; GB (n = 10) or RYGB (n = 11)]. Glucose homeostasis markers were measured under fasting conditions (glucose. insulin, and HbAlc) or during an oral glucose tolerance test. Fecal microbiota was analyzed using shotgun metagenomics, and A. muciniphila relative abundance was assessed with 16S rRNA quantitative PCR. A. muciniphila relative abundance was significantly lower in severe obesity [mean body mass index. 45.7 kg/m(2) (SD 5.4)] than in moderate obesity [33.2 kg/m(2) (SD 3.8)] but not associated with glucose homeostasis markers. A significant increase in A. muciniphila relative abundance after RYGB was not correlated with metabolic improvement. Baseline A. muciniphila abundance was correlated with bacterial gene richness and was highest in the high-richness Ruminococcaceae enterotype. A. muciniphila increased in relative abundance after BS in patients with low baseline A. muciniphila abundance, especially those with a Bacteroides type 2 enterotype classification. Although decreased in severe obesity, relative abundance of A. muciniphila was not associated with glucose homeostasis before or after BS. A certain level of A. muciniphila abundance might be required to observe a beneficial link to health. The severity of obesity and gut dysbiosis may partly explain the discrepancy with previous findings in less obese populations. specialized Akkermansia muciniphila bariatric surgery dysbiosis gut microbiota severe obesity 054 050 084 317 3 E446-E459 2019 0193-1849 https://www.documentation.ird.fr/hor/fdi:010077040 10.1152/ajpendo.00140.2019 0193-1849 [F B010077040] https://www.documentation.ird.fr/hor/fdi:010077040 https://www.documentation.ird.fr/intranet/publi/2019/10/010077040.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2019-11-05 2025-02-24 fdi:010077040 fre