@article{fdi:010077040,
  title = {{A}kkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement},
  author = {{D}ao, {M}. {C}. and {B}elda, {E}. and {P}rifti, {E}. and {E}verard, {A}. and {K}ayser, {B}. {D}. and {B}ouillot, {J}. {L}. and {C}hevallier, {J}. {M}. and {P}ons, {N}. and {L}e {C}hatelier, {E}. and {E}hrlich, {S}. {D}. and {D}or{\'e}, {J}. and {A}ron-{W}isnewsky, {J}. and {Z}ucker, {J}ean-{D}aniel and {C}ani, {P}. {D}. and {C}l{\'e}ment, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he gut bacterial species {A}kkermansia muciniphila is associated with a healthier clinical profile. {T}he purpose of this study was to determine the association between {A}. muciniphila and glucose homeostasis in patients undergoing bariatric surgery ({BS}): gastric banding ({GB}) or {R}oux-en-{Y} gastric bypass ({RYGB}). {T}his nonrandomized prospective study included 65 women with severe obesity. {L}ongitudinal analysis included subjects for whom {A}. muciniphila data were available at follow-up [1, 3, and 12 mo; {GB} (n = 10) or {RYGB} (n = 11)]. {G}lucose homeostasis markers were measured under fasting conditions (glucose. insulin, and {H}b{A}lc) or during an oral glucose tolerance test. {F}ecal microbiota was analyzed using shotgun metagenomics, and {A}. muciniphila relative abundance was assessed with 16{S} r{RNA} quantitative {PCR}. {A}. muciniphila relative abundance was significantly lower in severe obesity [mean body mass index. 45.7 kg/m(2) ({SD} 5.4)] than in moderate obesity [33.2 kg/m(2) ({SD} 3.8)] but not associated with glucose homeostasis markers. {A} significant increase in {A}. muciniphila relative abundance after {RYGB} was not correlated with metabolic improvement. {B}aseline {A}. muciniphila abundance was correlated with bacterial gene richness and was highest in the high-richness {R}uminococcaceae enterotype. {A}. muciniphila increased in relative abundance after {BS} in patients with low baseline {A}. muciniphila abundance, especially those with a {B}acteroides type 2 enterotype classification. {A}lthough decreased in severe obesity, relative abundance of {A}. muciniphila was not associated with glucose homeostasis before or after {BS}. {A} certain level of {A}. muciniphila abundance might be required to observe a beneficial link to health. {T}he severity of obesity and gut dysbiosis may partly explain the discrepancy with previous findings in less obese populations.},
  keywords = {{A}kkermansia muciniphila ; bariatric surgery ; dysbiosis ; gut microbiota ; severe obesity},
  booktitle = {},
  journal = {{A}merican {J}ournal of {P}hysiology : {E}ndocrinology and {M}etabolism},
  volume = {317},
  numero = {3},
  pages = {{E}446--{E}459},
  ISSN = {0193-1849},
  year = {2019},
  DOI = {10.1152/ajpendo.00140.2019},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077040},
}