EPPICC.European pregnancy and apediatric HIV cohort collaboration study group auteur aut IRD Crichton S. auteur aut IRD Belfrage E. auteur aut IRD Collins I.J. auteur aut IRD Doerholt K. auteur aut IRD Judd A. auteur aut IRD Le Coeur S. auteur aut IRD Spoulou V. auteur aut IRD Goodall R. auteur aut IRD Scherpbier H. auteur aut IRD Smit C. auteur aut IRD Goetghebuer T. auteur aut IRD Gibb D.M. auteur aut IRD Noguera A. auteur aut IRD Navarro M.L. auteur aut IRD Ramos J.T. auteur aut IRD Galli L. auteur aut IRD Giaquinto C. auteur aut IRD Thorne C. auteur aut IRD Ansone S. auteur aut IRD Marczynska M. auteur aut IRD Okhonskaia L. auteur aut IRD Martinez de Tejada B. auteur aut IRD Jourdain Gonzague auteur aut IRD Decker Luc auteur aut IRD Ene L. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Objective: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. Design: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. Methods: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. Results: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8,9.0] years and -1.2 (IQR: -2.3 to 0.2), respectively. Median follow-up was 9.1 (IQR:6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20- 0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth int later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least-1 maintained a similar height to the WHO reference mean. Conclusion: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age. specialized THAILANDE EUROPE IRLANDE ROYAUME UNI BELGIQUE GRECE LETTONIE PAYS BAS POLOGNE ROUMANIE ESPAGNE SUEDE SUISSE 052MALTRA03 050EPID 33 12 1897-1910 2019 0269-9370 https://www.documentation.ird.fr/hor/fdi:010076957 10.1097/qad.0000000000002294 0269-9370 [F B010076957] https://www.documentation.ird.fr/hor/fdi:010076957 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-11/010076957.pdf IRD - Base Horizon / Pleins textes 2019-11-19 2025-02-24 fdi:010076957 fre