%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A EPPICC.European pregnancy and apediatric HIV cohort collaboration study group
%A Crichton, S.
%A Belfrage, E.
%A Collins, I.J.
%A Doerholt, K.
%A Judd, A.
%A Le Coeur, S.
%A Spoulou, V.
%A Goodall, R.
%A Scherpbier, H.
%A Smit, C.
%A Goetghebuer, T.
%A Gibb, D.M.
%A Noguera, A.
%A Navarro, M.L.
%A Ramos, J.T.
%A Galli, L.
%A Giaquinto, C.
%A Thorne, C.
%A Ansone, S.
%A Marczynska, M.
%A Okhonskaia, L.
%A Martinez de Tejada, B.
%A Jourdain, Gonzague
%A Decker, Luc
%A Ene, L.
%T Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand
%D 2019
%L fdi:010076957
%G ENG
%J AIDS
%@ 0269-9370
%K THAILANDE ; EUROPE ; IRLANDE ; ROYAUME UNI ; BELGIQUE ; GRECE ; LETTONIE ; PAYS BAS ; POLOGNE ; ROUMANIE ; ESPAGNE ; SUEDE ; SUISSE
%M ISI:000507295000010
%N 12
%P 1897-1910
%R 10.1097/qad.0000000000002294
%U https://www.documentation.ird.fr/hor/fdi:010076957
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-11/010076957.pdf
%V 33
%W Horizon (IRD)
%X Objective: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. Design: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. Methods: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. Results: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8,9.0] years and -1.2 (IQR: -2.3 to 0.2), respectively. Median follow-up was 9.1 (IQR:6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20- 0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth int later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least-1 maintained a similar height to the WHO reference mean. Conclusion: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age.
%$ 052MALTRA03 ; 050EPID