@article{fdi:010076773,
  title = {{E}arly and late virologic failure after virologic suppression in {HIV}-infected {A}sian children and adolescents},
  author = {{M}u, {W}. {W}. and {B}artlett, {A}. {W}. and {B}unupuradah, {T}. and {C}hokephaibulkit, {K}. and {K}umarasamy, {N}. and {L}y, {P}. {S}. and {H}ansudewechakul, {R}. and {N}guyen, {L}. {V}. and {L}umbiganon, {P}. and {S}udjaritruk, {T}. and {M}ohamed, {T}. {A}. {J}. and {Y}usoff, {N}. {K}. {N}. and {T}ruong, {K}. {H}. and {D}o, {V}. {C}. and {F}ong, {M}. {S}. and {N}allusamy, {R}. and {K}urniati, {N}. and {W}ati, {D}. {K}. and {S}ohn, {A}. {H}. and {K}ariminia, {A}. and {Z}hang, {F}. {J}. and {L}y, {P}. {S}. and {K}hol, {V}. and {S}eng, {R}. and {T}ucker, {J}. and {K}umarasamy, {N}. and {C}handrasekaran, {E}. and {W}ati, {D}. {K}. and {V}edaswari, {D}. and {R}amajaya, {I}. {B}. and {K}urniati, {N}. and {M}uktiarti, {D}. and {F}ong, {S}. {M}. and {W}ong, {K}. {J}. and {D}aut, {F}. {B}. and {Y}usoff, {N}. {K}. {N}. and {M}ohamad, {P}. and {M}ohamed, {T}. {J}. and {D}rawis, {M}. {R}. and {N}allusamy, {R}. and {C}han, {K}. {C}. and {S}udjaritruk, {T}. and {S}irisanthana, {V}. and {A}urpibul, {L}. and {H}ansudewechakul, {R}. and {O}unchanum, {P}. and {D}enjanta, {S}. and {K}ongponoi, {A}. and {L}umbiganon, {P}. and {K}osalaraksa, {P}. and {T}harnprisan, {P}. and {U}domphanit, {T}. and {J}ourdain, {G}onzague and {P}uthanakit, {T}. and {A}nugulruengkit, {S}. and {J}antarabenjakul, {W}. and {N}adsasarn, {R}. and {C}hokephaibulkit, {K}. and {L}apphra, {K}. and {P}hongsamart, {W}. and {V}anprapar, {N}. and {T}ruong, {K}. {H}. and {D}u, {Q}. {T}. and {N}guyen, {T}. {T}. and {D}o, {V}. {C}. and {H}a, {T}. {M}. and {A}n, {V}. {T}. and {N}guyen, {L}. {V}. and {K}hu, {D}. {T}. {K}. and {N}guyen, {L}. {T}. and {L}e, {O}. {N}. and {S}ohn, {A}. {H}. and {R}oss, {J}. {L}. and {S}ethaputra, {C}. and {C}ooper, {D}. {A}. and {L}aw, {M}. {G}. and {K}ariminia, {A}. and {TREAT} {A}sia {P}ediatric {HIV} {O}bservational {D}atabase of {I}e{DEA} {A}sia-{P}acific},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {V}irologic failure is a major threat to maintaining effective combination antiretroviral therapy, especially for children in need of lifelong treatment. {W}ith efforts to expand access to {HIV} viral load testing, our understanding of pediatric virologic failure is evolving. {S}etting: {A}n {A}sian cohort in 16 pediatric {HIV} services across 6 countries. {M}ethods: {F}rom 2005 to 2014, patients younger than 20 years who achieved virologic suppression and had subsequent viral load testing were included. {E}arly virologic failure was defined as a {HIV} {RNA} >= 1000 copies per milliliter within 12 months of virologic suppression, and late virologic as a {HIV} {RNA} >= 1000 copies per milliliter after 12 months following virologic suppression. {C}haracteristics at combination antiretroviral therapy initiation and virologic suppression were described, and a competing risk time-to-event analysis was used to determine cumulative incidence of virologic failure and factors at virologic suppression associated with early and late virologic failure. {R}esults: {O}f 1105 included in the analysis, 182 (17.9%) experienced virologic failure. {T}he median age at virologic suppression was 6.9 years, and the median time to virologic failure was 24.6 months after virologic suppression. {T}he incidence rate for a first virologic failure event was 3.3 per 100 person-years. {F}actors at virologic suppression associated with late virologic failure included older age, mostly rural clinic setting, tuberculosis, protease inhibitor-based regimens, and early virologic failure. {N}o risk factors were identified for early virologic failure. {C}onclusions: {A}round 1 in 5 experienced virologic failure in our cohort after achieving virologic suppression. {T}argeted interventions to manage complex treatment scenarios, including adolescents, tuberculosis coinfection, and those with poor virologic control are required.},
  keywords = {virologic failure ; {HIV} ; children ; adolescents ; {ASIE}},
  booktitle = {},
  journal = {{JAIDS}.{J}ournal of {A}cquired {I}mmune {D}eficiency {S}yndromes},
  volume = {80},
  numero = {3},
  pages = {308--315},
  ISSN = {1525-4135},
  year = {2019},
  DOI = {10.1097/qai.0000000000001921},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076773},
}