@article{fdi:010076674,
  title = {{G}enomic evidence for local adaptation of hunter-gatherers to the {A}frican rainforest},
  author = {{L}opez, {M}. and {C}hoin, {J}. and {S}ikora, {M}. and {S}iddle, {K}. and {H}armant, {C}. and {C}osta, {H}. {A}. and {S}ilvert, {M}. and {M}ouguiama-{D}aouda, {P}. and {H}ombert, {J}. {M}. and {F}roment, {A}lain and {L}e {B}omin, {S}. and {P}erry, {G}. {H}. and {B}arreiro, {L}. {B}. and {B}ustamante, {C}. {D}. and {V}erdu, {P}. and {P}atin, {E}. and {Q}uintana-{M}urci, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}frican rainforests support exceptionally high biodiversity and host the world's largest number of active hunter-gatherers [1-3]. {T}he genetic history of {A}frican rainforest hunter-gatherers and neighboring farmers is characterized by an ancient divergence more than 100,000 years ago, together with recent population collapses and expansions, respectively [4-12]. {W}hile the demographic past of rainforest hunter-gatherers has been deeply characterized, important aspects of their history of genetic adaptation remain unclear. {H}ere, we investigated how these groups have adapted-through classic selective sweeps, polygenic adaptation, and selection since admixture-to the challenging rainforest environments. {T}o do so, we analyzed a combined dataset of 566 high-coverage exomes, including 266 newly generated exomes, from 14 populations of rainforest hunter-gatherers and farmers, together with 40 newly generated, low-coverage genomes. {W}e find evidence for a strong, shared selective sweep among all hunter-gatherer groups in the regulatory region of {TRPS}1-primarily involved in morphological traits. {W}e detect strong signals of polygenic adaptation for height and life history traits such as reproductive age; however, the latter appear to result from pervasive pleiotropy of height-associated genes. {F}urthermore, polygenic adaptation signals for functions related to responses of mast cells to allergens and microbes, the {IL}-2 signaling pathway, and host interactions with viruses support a history of pathogen-driven selection in the rainforest. {F}inally, we find that genes involved in heart and bone development and immune responses are enriched in both selection signals and local hunter-gatherer ancestry in admixed populations, suggesting that selection has maintained adaptive variation in the face of recent gene flow from farmers.},
  keywords = {{AFRIQUE} {CENTRALE} ; {CONGO} {BASSIN} ; {CAMEROUN} ; {GABON} ; {OUGANDA}},
  booktitle = {},
  journal = {{C}urrent {B}iology},
  volume = {29},
  numero = {17},
  pages = {2926--2935 + 4 p.},
  ISSN = {0960-9822},
  year = {2019},
  DOI = {10.1016/j.cub.2019.07.013},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076674},
}