@article{fdi:010076610,
  title = {{B}lood lead level in infants and subsequent risk of malaria : a prospective cohort study in {B}enin, {S}ub-{S}aharan {A}frica},
  author = {{G}arrison, {A}. and {K}hoshnood, {B}. and {C}ourtin, {D}avid and {M}ilet, {J}acqueline and {G}arcia, {A}ndr{\'e} and {M}assougbodji, {A}. and {A}yotte, {P}. and {C}ot, {M}ichel and {B}odeau-{L}ivinec, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}ead and malaria both present significant health risks to children in {S}ub-{S}aharan {A}frica. {P}revious studies have shown that high blood lead levels in children act as a protective factor against subsequent malaria incidence. {T}he main objective of this study was to investigate associations between blood lead level and malaria outcomes prospectively in {B}eninese children from 12 to 24 months of age. {T}wo-hundred and four children were assessed for lead at 12 months and closely followed until 24 months for malaria; when symptoms and parasite density were also recorded. {U}nivariate and multivariate negative binomial and linear regression models tested associations between blood lead level quartile and total episodes of malaria (total symptomatic and asymptomatic episodes) and parasite density, respectively. {M}edian blood lead level among children measured at 12 months was 56.50 (4.81-578) mu g/{L}. {D}uring the 12-month follow-up, 172 (84.31%) children had at least one malaria episode. {U}nivariate and multivariate negative binomial and linear regressions did not reveal significant associations between blood lead level quartile and malaria outcomes. {I}ron deficiency was not found to be an effect modifier. {R}esults from this prospective child-cohort study investigating associations between blood lead level and malaria did not confirm results from previous cross-sectional studies. {F}urther research is needed to further explore this relationship and other co-morbidities due to malaria and lead.},
  keywords = {{BENIN} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {14},
  numero = {7},
  pages = {art. e0220023 [14 ]},
  ISSN = {1932-6203},
  year = {2019},
  DOI = {10.1371/journal.pone.0220023},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076610},
}