@article{fdi:010076585,
  title = {{I}mpact of antiretroviral treatment on height evolution of {HIV} infected children},
  author = {{T}raisathit, {P}. and {U}rien, {S}. and {L}e {C}oeur, {S}. and {S}rirojana, {S}. and {A}karathum, {N}. and {K}anjanavanit, {S}. and {N}gampiyaskul, {C}. and {K}rikajornkitti, {S}. and {N}go-{G}iang-{H}uong, {N}icole and {L}allemant, {M}arc and {J}ourdain, {G}onzague},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {A}ntiretroviral treatment ({ART}) has been shown to have a beneficial effect on the weight evolution but its effect on height remains unclear. {W}e described patterns of height evolution and identified predictors of catch-up growth in {HIV}-infected children on {ART}. {M}ethods {T}o describe the height evolution from birth to adulthood, we developed a nonlinear mixed effect model using data from perinatally {HIV}-infected children who initiated {ART} from 1999 to 2013 in a prospective cohort study in {T}hailand. {T}he main covariates of interest were: sex, {ART} regimen (dual nucleoside reverse-transcriptase inhibitor, non-nucleoside reverse transcriptase inhibitor ({NNRTI})-, or protease inhibitor ({PI})-based), baseline {CD}4 percentage, {HIV}-{RNA} load and {CDC} {HIV} {C}lassification stage and occurrence of {AIDS}-defining events. {R}esults {A} total 477 children (43% boys) contributed 18,596 height measurements over a median duration of 6.3 years on {ART} (interquartile range, 3.0 to 8.3). {A}t {ART} initiation, median age was 6.2 years (1.8 to 9.6), 16% of children were underweight (weight-for-age z-score < - 2), 49% presented stunting (height-for-age z-score < - 2), and 7% wasting (weight-for-height z-score < - 2). {T}he most frequent regimen at {ART} initiation was {NNRTI}-based (79%). {A} model with 4 components, birth length and 3 exponential functions of age accounting for the 3 growth phases was developed and show that the height-growth velocity was inversely associated with the age at {ART} initiation, the adult height was significantly lower in those who had experienced at least one {AIDS}-defining event while, as expected, the model found that adult height in females was lower than in males. {A}ge at {ART} initiation, type of {ART} regimen, {CDC} stage, {CD}4 percentages, and {HIV}-{RNA} load were not associated with the final height. {C}onclusions {T}he younger the children at {ART} initiation, the greater the effect on height-growth velocity, supporting the {W}orld {H}ealth {O}rganization's recommendation to start {ART} as early as possible. {H}owever, final adult height was not linked to the age at {ART} initiation.},
  keywords = {{A}sia ; antiretroviral therapy ; catch-up growth ; height-growth velocity ; {HIV}-infected children ; {T}hailand ; {THAILANDE}},
  booktitle = {},
  journal = {{BMC} {P}ediatrics},
  volume = {19},
  numero = {1},
  pages = {art. 287 [9 ]},
  year = {2019},
  DOI = {10.1186/s12887-019-1663-8},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076585},
}