@article{fdi:010076579,
  title = {{P}redictors of faster virological suppression in early treated infants with perinatal {HIV} from {E}urope and {T}hailand},
  author = {{C}han, {M}. {K}. and {G}oodall, {R}. and {J}udd, {A}. and {K}lein, {N}. and {C}hiappini, {E}. and {K}limkait, {T}. and {N}go-{G}iang-{H}uong, {N}icole and {P}alma, {P}. and {R}ossi, {P}. and {T}horne, {C}. and {T}urkova, {A}. and {Z}angari, {P}. and {R}ojo, {P}. and {B}abiker, {A}. {G}. {A}. and {F}raaij, {P}. {L}. and {P}ajkrt, {D}. and {M}arques, {L}. and {C}ollins, {I}. {J}. and {G}ibb, {D}. {M}. and {G}onzalez-{T}ome, {M}. {I}. and {R}amos, {J}. {T}. and {N}avarro, {M}. {L}. and {N}oguera-{J}ulian, {A}. and {W}arszawski, {J}. and {K}onigs, {C}. and {S}poulou, {V}. and {P}rata, {F}. and {G}oetghebuer, {T}. and {G}alli, {L}. and {N}aver, {L}. and {G}iaquinto, {C}. and {M}arczynska, {M}. and {O}khonskaia, {L}. and {M}alyuta, {R}. and {V}olokha, {A}. and {E}ne, {L}. and {G}ibb, {D}. and {W}atters, {S}. and {C}han, {M}. and {M}c{C}oy, {L}. and {B}abiker, {A}. and {M}arcelin, {A}. {G}. and {C}alvez, {V}. and {M}unoz, {M}. {A}. and {W}ahren, {B}. and {F}oster, {C}. and {C}otton, {M}. and {R}obb, {M}. and {A}nanworanich, {J}. and {C}laiden, {P}. and {P}illay, {D}. and {P}ersaud, {D}. and {D}e {B}oer, {R}. {J}. and {S}chroter, {J}. and {A}nelone, {A}. {J}. {N}. and {P}uthanakit, {T}. and {C}eci, {A}. and {G}iannuzzi, {V}. and {L}uzuriaga, {K}. and {C}homont, {N}. and {C}ameron, {M}. and {C}ancrini, {C}. and {Y}ates, {A}. and {K}uhn, {L}. and {V}iolari, {A}. and {O}twombe, {K}. and {P}epponi, {I}. and {R}occhi, {F}. and {R}inaldi, {S}. and {T}agarro, {A}. and {L}ain, {M}. {G}. and {V}az, {P}. and {L}opez, {E}. and {N}hampossa, {T}. and {EPPICC} study group and {EPIICAL} study groups},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective: {T}o identify predictors of faster time to virological suppression among infants starting combination antiretroviral therapy (c{ART}) early in infancy. {D}esign: {C}ohort study of infants from {E}urope and {T}hailand included in studies participating in the {E}uropean {P}regnancy and {P}aediatric {HIV} {C}ohort {C}ollaboration. {M}ethods: {I}nfants with perinatal {HIV} starting c{ART} aged less than 6 months with at least 1 viral load measurement within 15 months of c{ART} initiation were included. {M}ulti-variable interval-censored flexible parametric proportional hazards models were used to assess predictors of faster virological suppression, with timing of suppression assumed to lie in the interval between last viral load at least 400 and first viral load less than 400 copies/ml. {R}esults: {O}f 420 infants, 59% were female and 56% from {C}entral/{W}estern {E}urope, 26% {U}nited {K}ingdom/{I}reland, 15% {E}astern {E}urope and 3% {T}hailand; 46 and 54% started a boosted protease inhibitor-based or nonnucleoside reverse transcriptase inhibitor-based regimen, respectively. {A}t c{ART} initiation, the median age, {CD}4(+) % and viral load were 2.9 [interquartile range ({IQR}): 1.4-4.1] months, 34 ({IQR}: 24-45)% and 5.5 ({IQR}: 4.5-6.0) log(10) copies/ml, respectively. {O}verall, an estimated 89% (95% confidence interval: 86-92%) achieved virological suppression within 12 months of c{ART} start. {I}n multivariable analysis, younger age [adjusted hazard ratio (a{HR}): 0.84 per month older; {P} < 0.001], higher {CD}4(+) % (a{HR}: 1.11 per 10% higher; {P}=0.010) and lower log(10) viral load (a{HR}: 0.85 per log(10) higher; {P} < 0.001) at c{ART} initiation independently predicted faster virological suppression. {C}onclusion: {W}e observed a significant independent effect of age at c{ART} initiation, even within a narrow 6 months window from birth. {T}hese findings support the earliest feasible c{ART} initiation in infants and suggest that early therapy influences key virological and immunological parameters that could have important consequences for long-term health.},
  keywords = {early combination antiretroviral therapy ; infants ; perinatal {HIV} ; predictors ; virological suppression ; {EUROPE} ; {THAILANDE}},
  booktitle = {},
  journal = {{AIDS}},
  volume = {33},
  numero = {7},
  pages = {1155--1165},
  ISSN = {0269-9370},
  year = {2019},
  DOI = {10.1097/qad.0000000000002172},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076579},
}