%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Avokpaho, E.
%A d'Almeida, T. C.
%A Sadissou, I.
%A Tokplonou, L.
%A Adamou, R.
%A Sonon, P.
%A Milet, Jacqueline
%A Cottrell, Gilles
%A Mondiere, A.
%A Massougbodji, A.
%A Moutairou, K.
%A Donadi, E. A.
%A Mendes, C. T.
%A Favier, B.
%A Carosella, E.
%A Moreau, P.
%A Rouas-Freiss, N.
%A Garcia, André
%A Courtin, David
%T HLA-G expression during hookworm infection in pregnant women
%D 2019
%L fdi:010076554
%G ENG
%J Acta Tropica
%@ 0001-706X
%K HLA-G ; Helminth ; Hookworm ; Immune tolerance ; Pregnant women ; Neglected tropical diseases
%K BENIN
%M ISI:000479023900009
%P 52-59
%R 10.1016/j.actatropica.2019.04.026
%U https://www.documentation.ird.fr/hor/fdi:010076554
%> https://www.documentation.ird.fr/intranet/publi/2019/08/010076554.pdf
%V 196
%W Horizon (IRD)
%X Introduction: HLA-G plays a key role on immune tolerance. Pathogens can induce soluble HLA-G (sHLA-G) production to down-regulate the host immune response, creating a tolerogenic environment favorable for their dissemination. To our knowledge, no study has yet been conducted to assess the relationship between sHLA-G and geohelminth infections. Methods: The study was conducted in Allada, Southeastern Benin, from 2011 - 2014. The study population encompassed 400 pregnant women, included before the end of the 28th week of gestation and followed-up until delivery. At two antenatal care visits and at delivery, stool and blood samples were collected. Helminths were diagnosed by means of the Kato-Katz concentration technique. We used quantile regression to analyze the association between helminth infections and sHLA-G levels during pregnancy. Results: sHLA-G levels gradually increased during pregnancy and reached maximal levels at delivery. Prevalence of helminth infections was low, with a majority of hookworm infections. We found significantly more hookworm-infected women above the 80th quantile (Q80) of the distribution of the mean sHLA-G level (p < 0.03, multivariate quantile regression). Considering only women above the Q80 percentile, the mean sHLA-G level was significantly higher in hookworm-infected compared to uninfected women (p = 0.04). Conclusion: High levels of sHLA-G were associated with hookworm infection in pregnant women. This result is consistent with the potential involvement of sHLA-G in immune tolerance induced by helminths during pregnancy.
%$ 052 ; 050