@article{fdi:010076554,
  title = {{HLA}-{G} expression during hookworm infection in pregnant women},
  author = {{A}vokpaho, {E}. and d'{A}lmeida, {T}. {C}. and {S}adissou, {I}. and {T}okplonou, {L}. and {A}damou, {R}. and {S}onon, {P}. and {M}ilet, {J}acqueline and {C}ottrell, {G}illes and {M}ondiere, {A}. and {M}assougbodji, {A}. and {M}outairou, {K}. and {D}onadi, {E}. {A}. and {M}endes, {C}. {T}. and {F}avier, {B}. and {C}arosella, {E}. and {M}oreau, {P}. and {R}ouas-{F}reiss, {N}. and {G}arcia, {A}ndr{\'e} and {C}ourtin, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction: {HLA}-{G} plays a key role on immune tolerance. {P}athogens can induce soluble {HLA}-{G} (s{HLA}-{G}) production to down-regulate the host immune response, creating a tolerogenic environment favorable for their dissemination. {T}o our knowledge, no study has yet been conducted to assess the relationship between s{HLA}-{G} and geohelminth infections. {M}ethods: {T}he study was conducted in {A}llada, {S}outheastern {B}enin, from 2011 - 2014. {T}he study population encompassed 400 pregnant women, included before the end of the 28th week of gestation and followed-up until delivery. {A}t two antenatal care visits and at delivery, stool and blood samples were collected. {H}elminths were diagnosed by means of the {K}ato-{K}atz concentration technique. {W}e used quantile regression to analyze the association between helminth infections and s{HLA}-{G} levels during pregnancy. {R}esults: s{HLA}-{G} levels gradually increased during pregnancy and reached maximal levels at delivery. {P}revalence of helminth infections was low, with a majority of hookworm infections. {W}e found significantly more hookworm-infected women above the 80th quantile ({Q}80) of the distribution of the mean s{HLA}-{G} level (p < 0.03, multivariate quantile regression). {C}onsidering only women above the {Q}80 percentile, the mean s{HLA}-{G} level was significantly higher in hookworm-infected compared to uninfected women (p = 0.04). {C}onclusion: {H}igh levels of s{HLA}-{G} were associated with hookworm infection in pregnant women. {T}his result is consistent with the potential involvement of s{HLA}-{G} in immune tolerance induced by helminths during pregnancy.},
  keywords = {{HLA}-{G} ; {H}elminth ; {H}ookworm ; {I}mmune tolerance ; {P}regnant women ; {N}eglected tropical diseases ; {BENIN}},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {196},
  numero = {},
  pages = {52--59},
  ISSN = {0001-706{X}},
  year = {2019},
  DOI = {10.1016/j.actatropica.2019.04.026},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076554},
}