@article{fdi:010076533,
  title = {{D}etection of {M}ycobacterium tuberculosis in paucibacillary sputum : performances of the {X}pert {MTB}/{RIF} ultra compared to the {X}pert {MTB}/{RIF}, and {IS}6110 {PCR}},
  author = {{K}olia-{D}iafouka, {P}. and {C}arrere-{K}remer, {S}. and {L}ounnas, {M}anon and {B}ourdin, {A}. and {K}remer, {L}. and {V}an de {P}erre, {P}. and {G}odreuil, {S}. and {T}uaillon, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {X}pert {MTB}/{RIF} {U}ltra assay has recently been launched to improve the detection of smear negative disease. {T}his retrospective study compares the sensitivity of {X}pert {MTB}/{RIF} {U}ltra with that of {X}pert {MTB}/{RIF} tests and {IS}6110 real-time {PCR} in sputum. {D}iagnostic performance of three molecular tests was evaluated using 48 culture-positive clinical respiratory specimens diluted to obtain paucibacillary sputum specimens. {X}pert {MTB}/{RIF} {U}ltra had the highest sensitivity of 100% compared to 42% ({P} < 0.001) for {X}pert {MTB}/{RIF} and 64.5% ({P} = 0.02) for {IS}6110-{PCR}. {A}ll "very low" or "low" positive specimens using {X}pert {MTB}/{RIF} {U}ltra were tested positive using {IS}6110-{PCR}, but 35.4% were found negative using {X}pert {MTB}/{RIF}. {X}pert {MTB}/{RIF} {U}ltra is more sensitive than the two other tests for sputum with a low bacterial load. {A}dding detection of {IS}6110 and {IS}1081 to rpo{B}, is a key evolution of the assay and improves the detection of {M}ycobacterium tuberculosis' {DNA} in paucibacillary sputum.},
  keywords = {{C}helex ({R}) ; {M}ycobacterium tuberculosis ; {IS}6110-{PCR} ; {X}pert {MTB}/{RIF} ; {X}pert ; {MTB}/{RIF} ultra ; {P}aucibacillary sputum},
  booktitle = {},
  journal = {{D}iagnostic {M}icrobiology and {I}nfectious {D}isease},
  volume = {94},
  numero = {4},
  pages = {365--370},
  ISSN = {0732-8893},
  year = {2019},
  DOI = {10.1016/j.diagmicrobio.2019.02.008},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076533},
}