@techreport{fdi:010076301,
  title = {{E}bola outbreak brings to light an unforeseen impact of tsetse control on sleeping sickness transmission in {G}uinea},
  author = {{K}agabadouno, {M}. and {C}amara, {O}. and {I}lboudo, {H}. and {C}amara, {M}. and {R}ayaisse, {J}.{B}. and {D}iaby, {A}. and {T}raor{\'e}, {B}. and {L}eno, {M}. and {C}ourtin, {F}abrice and {J}amonneau, {V}incent and {S}olano, {P}hilippe and {B}ucheton, {B}runo},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n addition to the thousands of deaths due the unprecedented ebola outbreak that stroke {W}est {A}frica (2014-2016), national health systems in affected countries were deeply challenged impacting a number of diseases control programs. {H}ere we describe the case of {H}uman {A}frican {T}rypanosomiasis ({HAT}), a deadly neglected tropical disease due to a trypanosome transmitted by tsetse flies for which no vaccine nor chemoprophylaxis exists. {D}ata are presented for the disease focus of {B}offa in {G}uinea where a pilot elimination project combining medical screening and vector control was launched in 2012. {D}uring ebola, {HAT} active screening activities were postponed and passive surveillance also was progressively impaired. {H}owever, tsetse control using small insecticide impregnated targets could be maintained. {T}he over two years disruption of screening activities led to a dramatic increase of {HAT} prevalence, from 0.7% in 2013 (21/2885) to 2% (69/3448) in 2016, reaching epidemic levels (>5%) in some villages. {I}n deep contrast, control levels reached in 2013 (0.1%; 7/6564) were maintained in areas covered with impregnated targets as no cases were found in 2016 (0/799). {I}n {B}offa, ebola has thus incidentally provided a unique framework to assess the impact of current {HAT} control strategies. {A} first lesson is that the "screen and treat" strategy is fragile as rapid bursts of the disease may occur in case of disruption. {A} second lesson is that vector control reducing human-tsetse contacts, even implemented alone, is effective in providing a good level of protection against infection. {T}his advocates for a greater attention being paid to the combination of tsetse control together with medical activities in aiming to reach the {HAT} elimination objective in {A}frica.},
  keywords = {{EPIDEMIE} ; {TRYPANOSOMIASE} {HUMAINE} ; {MALADIE} {DU} {SOMMEIL} ; {SURVEILLANCE} ; {PREVALENCE} ; {FIEVRE} {HEMORRAGIQUE} ; {PROGRAMME} {DE} {RECHERCHE} ; {METHODE} {DE} {LUTTE} ; {EBOLA} ; {GUINEE} {MARITIME} ; {BOFFA}},
  address = {},
  series = {{B}io{R}xiv},
  pages = {en ligne [9 ]},
  year = {2018},
  DOI = {10.1101/202762},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076301},
}