@article{fdi:010076287, title = {{P}lasmodium falciparum merozoite surface antigen-specific cytophilic {I}g{G} and control of malaria infection in a {B}eninese birth cohort}, author = {{A}damou, {R}. and {D}echavanne, {C}{\'e}lia and {S}adissou, {I}. and {D}'{A}lmeida, {T}. and {B}ouraima, {A}. and {S}onon, {P}. and {A}moussa, {R}. and {C}ottrel, {G}illes and {L}e {P}ort, {A}. and {T}heisen, {M}. and {R}emarque, {E}.{J}. and {L}ongacre, {S}. and {M}outairou, {K}. and {M}assougbodji, {A}. and {L}uty, {A}drian and {N}uel, {G}. and {M}igot {N}abias, {F}lorence and {S}anni, {A}. and {G}arcia, {A}ndr{\'e} and {M}ilet, {J}acqueline}, editor = {}, language = {{ENG}}, abstract = {{B}ackground : {S}ubstantial evidence indicates that cytophilic {I}g{G} responses to {P}lasmodiumfalciparum merozoite antigens play a role in protection from malaria. {T}he specific targets mediating immunity remain unclear. {E}valuating antibody responses in infants naturally-exposed to malaria will allow to better understand the establishment of anti-malarial immunity and to contribute to a vaccine development by identifying the most appropriate merozoite candidate antigens. {M}ethods : {T}he study was based on parasitological and clinical active follow-up of infants from birth to 18months of age conducted in the {T}ori {B}ossito area of southern {B}enin. {F}or 399 infants, plasma levels of cytophilic {I}g{G} antibodies with specificity for five asexual stage malaria vaccine candidate antigens were determined by {ELISA} in infants' peripheral blood at 6, 9, 12 and 15months of age. {M}ultivariate mixed logistic model was used to investigate the association between antibody levels and anti-malarial protection in the trimester following the {I}g{G} quantification. {M}oreover, the concentrations of merozoite antigen-specific {I}g{G} were compared between a group of infants apparently able to control asymptomatic malaria infection ({CAIG}) and a group of infants with no control of malaria infection ({C}ontrol group ({NCIG})). {P}rotective effect of antibodies was also assessed after 15months of malaria exposure with a {C}ox regression model adjusted on environmental risk. {R}esults : {C}ytophilic {I}g{G} responses to {AMA}1, {MSP}1, {MSP}2-3{D}7, {MSP}2-{FC}27, {MSP}3 and {GLURP} {R}2 were associated with increasing malarial infection risk in univariate analysis. {T}he multivariate mixed model showed that {I}g{G}1 and {I}g{G}3 to {AMA}1 were associated with an increased risk of malarial infection. {H}owever infants from {CAIG} (n=53) had significantly higher {AMA}1-, {MSP}2-{FC}27-, {MSP}3-specific {I}g{G}1 and {AMA}1-, {MSP}1-, {MSP}2-{FC}27-, {MSP}3 and {GLURP}-{R}2-specific {I}g{G}3 than those from {NCIG} (n=183). {T}he latter {I}g{G} responses were not associated with protection against clinical malaria in the whole cohort when protective effect is assessed after 15months of malaria exposition. {C}onclusion : {I}n this cohort, merozoite antigen-specific cytophilic {I}g{G} levels represent a marker of malaria exposure in infants from 6 to 18 months of age. {H}owever, infants with resolution of asymptomatic infection ({CAIG}) seem to have acquired naturally immunity against {P}. falciparum. {T}his observation is encouraging in the context of the development of multitarget {P}. falciparum vaccines.}, keywords = {{PALUDISME} ; {IMMUNOLOGIE} ; {ENFANT} {D}'{AGE} {PRESCOLAIRE} ; {NOURRISSON} ; {PARASITE} ; {ANTIGENE} ; {ANTICORPS} ; {VACCINATION} ; {MILIEU} {RURAL} ; {FACTEUR} {DE} {RISQUE} ; {BENIN} ; {TORI} {BOSSITO}}, booktitle = {}, journal = {{M}alaria {J}ournal}, volume = {18}, numero = {}, pages = {art. no 194 [11 ]}, ISSN = {1475-2875}, year = {2019}, DOI = {10.1186/s12936-019-2831-x}, URL = {https://www.documentation.ird.fr/hor/fdi:010076287}, }