@article{fdi:010076254,
  title = {{C}ontribution of asymptomatic {P}lasmodium infections to the transmission of malaria in {K}ayin {S}tate, {M}yanmar},
  author = {{C}haumeau, {V}. and {K}ajeechiwa, {L}. and {F}ustec, {B}{\'e}n{\'e}dicte and {L}andier, {J}ordi and {N}yo, {S}. {N}. and {H}sel, {S}. {N}. and {P}hatharakokordbun, {P}. and {K}ittiphanakun, {P}. and {N}osten, {S}. and {T}hwin, {M}. {M}. and {T}un, {S}. {W}. and {W}iladphaingern, {J}. and {C}ottrell, {G}illes and {P}arker, {D}. {M}. and {M}inh, {M}. {C}. and {K}wansomboon, {N}. and {M}etaane, {S}. and {M}ontazeau, {C}{\'e}line and {K}unjanwong, {K}. and {S}awasdichai, {S}. and {A}ndolina, {C}. and {L}ing, {C}. and {H}aohankhunnatham, {W}. and {C}hristiensen, {P}. and {W}anyatip, {S}. and {K}onghahong, {K}. and {C}erqueira, {D}. and {I}mwong, {M}. and {D}ondorp, {A}. {M}. and {C}hareonviriyaphap, {T}. and {W}hite, {N}. {J}. and {N}osten, {F}. {H}. and {C}orbel, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {T}he objective of mass antimalarial drug administration ({MDA}) is to eliminate malaria rapidly by eliminating the asymptomatic malaria parasite reservoirs and interrupting transmission. {I}n the {G}reater {M}ekong {S}ubregion, where artemisinin-resistant {P}lasmodium falciparum is now widespread, {MDA} has been proposed as an elimination accelerator, but the contribution of asymptomatic infections to malaria transmission has been questioned. {T}he impact of {MDA} on entomological indices has not been characterized previously. {M}ethods. {MDA} was conducted in 4 villages in {K}ayin {S}tate ({M}yanmar). {M}alaria mosquito vectors were captured 3 months before, during, and 3 months after {MDA}, and their {P}lasmodium infections were detected by polymerase chain reaction ({PCR}) analysis. {T}he relationship between the entomological inoculation rate, the malaria prevalence in humans determined by ultrasensitive {PCR}, and {MDA} was characterized by generalized estimating equation regression. {R}esults. {A}symptomatic {P}. falciparum and {P}lasmodium vivax infections were cleared by {MDA}. {T}he {P}. vivax entomological inoculation rate was reduced by 12.5-fold (95% confidence interval [{CI}], 1.6-100-fold), but the reservoir of asymptomatic {P}. vivax infections was reconstituted within 3 months, presumably because of relapses. {T}his was coincident with a 5.3-fold (95% {CI}, 4.8-6.0-fold) increase in the vector infection rate. {C}onclusion. {A}symptomatic infections are a major source of malaria transmission in {S}outheast {A}sia.},
  keywords = {{M}ass drug administration ; malaria ; entomological inoculation rate ; primaquine ; {P}lasmodium falciparum ; {P}lasmodium vivax ; elimination ; artemisinin resistance ; {S}outheast {A}sia ; {MYANMAR}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {219},
  numero = {9},
  pages = {1499--1509},
  ISSN = {0022-1899},
  year = {2019},
  DOI = {10.1093/infdis/jiy686},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076254},
}