Carboué Q. auteur aut IRD Rebufa C. auteur aut IRD Dupuy N. auteur aut IRD Roussos Sevastianos auteur aut IRD Bombarda I. auteur aut IRD text journalArticle eng text/pdf born digital access Plug flow bioreactor (PFB) used in solid state fermentation gives the possibility to have semicontinuous culture. However, it is complicated to follow a single particle during its residence inside the bioreactor and to therefore study precisely the culture process all along the device. In this study, semicontinuous production of fungal compounds was successfully obtained by cultivating Aspergillus niger with a PFB prototype. Kinetic productions of the same metabolites along the bioreactor were obtained at laboratory scale to predict the residence time of the particles inside the PFB from Partial Least Square (PLS). This original methodology allowed (1) the comparison between the production kinetics at the two production scales (pilot and laboratory) and (2) the observation of eventual changes following the scale-up of the process offering a good overall insight of the PFB performance. specialized Plug flow bioreactor Solid state fermentation Partial least square regression Residence time Aspergillus niger 084 149 art. 107248 [9 ] 2019 1369-703X https://www.documentation.ird.fr/hor/fdi:010076246 10.1016/j.bej.2019.107248 1369-703X [F B010076246] https://www.documentation.ird.fr/hor/fdi:010076246 https://www.documentation.ird.fr/intranet/publi/2019/08/010076246.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2019-09-19 2025-02-24 fdi:010076246 fre