Agbota G. auteur aut IRD Accrombessi M. auteur aut IRD Cottrell Gilles auteur aut IRD Martin-Prével Yves auteur aut IRD Milet Jacqueline auteur aut IRD Ouedraogo S. auteur aut IRD Courtin David auteur aut IRD Massougbodji A. auteur aut IRD Garcia André auteur aut IRD Cot Michel auteur aut IRD Briand Valérie auteur aut IRD text journalArticle eng text/pdf born digital access Background. According to the Developmental Origins of Health and Diseases paradigm, the fetal period is highly vulnerable and may have profound effects on later health. Few studies assessed the effect of small-for-gestational age (SGA), a proxy for fetal growth impairment, on risk of malaria during infancy in Africa. Methods. We used data from a cohort of 398 mother-child pairs, followed from early pregnancy to age 1 year in Benin. Malaria was actively and passively screened using thick blood smear. We assessed the effect of SGA on risk of malaria infection and clinical malaria from birth to 12 months, after stratifying on the infant's age using a logistic mixed regression model. Results. After adjustment for potential confounding factors and infant's exposure to mosquitoes, SGA was associated with a 2-times higher risk of malaria infection (adjusted odds ratio [aOR] = 2.16; 95% confidence interval [CI], 1.04-4.51; P = .039) and clinical malaria (aOR = 2.33; 95% CI, 1.09-4.98; P = .030) after age 6 months. Conclusion. Results suggest higher risk of malaria during the second semester of life in SGA infants, and argue for better follow-up of these infants after birth, as currently for preterm babies. specialized DOHaD small for gestational age malaria infancy epidemiology cohort BENIN 050 052 219 10 1642-1651 2019 0022-1899 https://www.documentation.ird.fr/hor/fdi:010076182 10.1093/infdis/jiy699 0022-1899 [F B010076182] https://www.documentation.ird.fr/hor/fdi:010076182 https://www.documentation.ird.fr/intranet/publi/2019/07/010076182.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2019-08-05 2025-02-24 fdi:010076182 fre