%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A d'Almeida, T. C.
%A Sadissou, I.
%A Sagbohan, M.
%A Milet, Jacqueline
%A Avokpaho, E.
%A Gineau, L.
%A Sabbagh, A.
%A Moutairou, K.
%A Donadi, E. A.
%A Favier, B.
%A Pennetier, Cédric
%A Baldet, T.
%A Moiroux, Nicolas
%A Carosella, E.
%A Moreau, P.
%A Rouas-Freiss, N.
%A Cottrell, Gilles
%A Courtin, David
%A Garcia, André
%T High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy
%D 2019
%L fdi:010076157
%G ENG
%J Scientific Reports - Nature
%@ 2045-2322
%K BENIN
%M ISI:000472597400063
%P art. 9160 [9 ]
%R 10.1038/s41598-019-45688-w
%U https://www.documentation.ird.fr/hor/fdi:010076157
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-07/010076157.pdf
%V 9
%W Horizon (IRD)
%X Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children were actively followed-up during 24 months. The results show a significant association between the level of sHLA-G at the first antenatal visit and the time to first malaria infection during infancy adjusted to the risk of exposure to vector bites (aHR = 1.02, 95% CI [1.01-1.03], p = 0.014). The level of sHLA-G is a significant predictor of the occurrence of malaria infection during infancy consistent with the hypothesis that mother sHLA-G could be a biomarker of malaria susceptibility in children.
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