@article{fdi:010076157,
  title = {{H}igh level of soluble human leukocyte antigen ({HLA})-{G} at beginning of pregnancy as predictor of risk of malaria during infancy},
  author = {d'{A}lmeida, {T}. {C}. and {S}adissou, {I}. and {S}agbohan, {M}. and {M}ilet, {J}acqueline and {A}vokpaho, {E}. and {G}ineau, {L}. and {S}abbagh, {A}. and {M}outairou, {K}. and {D}onadi, {E}. {A}. and {F}avier, {B}. and {P}ennetier, {C}{\'e}dric and {B}aldet, {T}. and {M}oiroux, {N}icolas and {C}arosella, {E}. and {M}oreau, {P}. and {R}ouas-{F}reiss, {N}. and {C}ottrell, {G}illes and {C}ourtin, {D}avid and {G}arcia, {A}ndr{\'e}},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lacental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. {HLA}-{G} is involved in fetal maternal immune tolerance by inhibiting maternal immunity. {D}uring infections {HLA}-{G} can be involved in immune escape of pathogens by creating a tolerogenic environment. {R}ecent studies have shown an association between the risk of malaria and {HLA}-{G} at both genetic and protein levels. {M}oreover, women with placental malaria have a higher probability of giving birth to children exhibiting high s{HLA}-{G}, independently of their own level during pregnancy. {O}ur aim was to explore the association between the level of maternal soluble {HLA}-{G} and the risk of malaria infection in their newborns. {H}ere, 400 pregnant women and their children were actively followed-up during 24 months. {T}he results show a significant association between the level of s{HLA}-{G} at the first antenatal visit and the time to first malaria infection during infancy adjusted to the risk of exposure to vector bites (a{HR} = 1.02, 95% {CI} [1.01-1.03], p = 0.014). {T}he level of s{HLA}-{G} is a significant predictor of the occurrence of malaria infection during infancy consistent with the hypothesis that mother s{HLA}-{G} could be a biomarker of malaria susceptibility in children.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {9},
  numero = {},
  pages = {art. 9160 [9 p.]},
  ISSN = {2045-2322},
  year = {2019},
  DOI = {10.1038/s41598-019-45688-w},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076157},
}