@article{fdi:010076115,
  title = {{I}dentification of {P}lasmodium falciparum and host factors associated with cerebral malaria : description of the protocol for a prospective, case-control study in {B}enin ({N}euro{CM})},
  author = {{J}oste, {V}. and {M}aurice, {L}. and {B}ertin, {G}wladys and {A}ubouy, {A}gn{\`e}s and {B}oumediene, {F}. and {H}ouze, {S}. and {A}jzenberg, {D}. and {A}rgy, {N}. and {M}assougbodji, {A}. and {D}ossou-{D}agba, {I}. and {A}lao, {M}. {J}. and {C}ot, {M}ichel and {D}eloron, {P}hilippe and {F}aucher, {J}. {F}. and {G}uemouri, {S}ayeh and {R}oyo, {J}ade and {N}euro{CM} {G}roup},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {I}n 2016, an estimated 216 million cases and 445 000 deaths of malaria occurred worldwide, in 91 countries. {I}n {B}enin, malaria causes 26.8% of consultation and hospitalisation motif in the general population and 20.9% in children under 5 years old. {T}he goal of the {N}euro{CM} project is to identify the causative factors of neuroinflammation in the context of cerebral malaria. {T}here are currently very few systematic data from {W}est {A}frica on the aetiologies and management of non-malarial non-traumatic coma in small children, and {N}euro{CM} will help to fill this gap. {W}e postulate that an accurate understanding of molecular and cellular mechanisms involved in neuroinflammation may help to define efficient strategies to prevent and manage cerebral malaria. {M}ethods and analysis {T}his is a prospective, case-control study comparing cerebral malaria to uncomplicated malaria and non-malarial non-traumatic coma. {T}his study takes place in {B}enin, precisely in {C}otonou for children with coma and in {S}o-{A}va district for children with uncomplicated malaria. {W}e aim to include 300 children aged between 24 and 71 months and divided in three different clinical groups during 12 months (from {D}ecember 2017 to {N}ovember 2018) with a 21 to 28 days follow-up for coma. {S}tudy data, including clinical, biological and research results will be collected and managed using {CSO}nline-{E}nnov {C}linical. {E}thics and dissemination {E}thics approval for the {N}euro{CM} study has been obtained from {C}omite {N}ational d'{E}thique pour la {R}echerche en sante of {B}enin (n degrees 67/ {MS}/{DC}/{SGM}/{DRFMT}/{CNERS}/{SA}; 10/17/2017). {N}euro{CM} study has also been approved by {C}omite consultatif de deontologie et d'ethique of {I}nstitut de {R}echerche pour le {D}eveloppement ({IRD}; 10/24/2017). {T}he study results will be disseminated through the direct consultations with the {WHO}'s {M}ultilateral {I}nitiative on {M}alaria ({TDR}-{MIM}) and {R}oll {B}ack {M}alaria programme, through scientific meetings and peer-reviewed publications in scientific or medical journals, and through guidelines and booklets.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{BMJ} {O}pen},
  volume = {9},
  numero = {5},
  pages = {art. no e027378 [ 9 ]},
  ISSN = {2044-6055},
  year = {2019},
  DOI = {10.1136/bmjopen-2018-027378},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076115},
}