@article{fdi:010076053,
  title = {{P}rior contact with permethrin decreases its irritancy at the following exposure among a pyrethroid-resistant malaria vector {A}nopheles gambiae},
  author = {{M}ulatier, {M}. and {P}ennetier, {C}{\'e}dric and {P}orciani, {A}ng{\'e}lique and {C}handre, {F}abrice and {D}ormont, {L}. and {C}ohuet, {A}nna},
  editor = {},
  language = {{ENG}},
  abstract = {{I}nsecticide-treated nets ({ITN}s) remain major components for vector control despite the spread of resistance mechanisms among mosquito populations. {M}ultiple exposures to pyrethroids may induce physiological and behavioral changes in mosquitoes, possibly reducing efficacy of control tools. {D}espite epidemiological relevance, the effects of multiple exposures to pyrethroids on their efficacy against pyrethroid-resistant mosquitoes has received little interest. {I}n the present study, we assessed the effects of a blood-meal successfully obtained upon a permethrin-treated net on the success at taking a second blood-meal in presence of permethrin in {A}nopheles gambiae, carrying pyrethroid resistance alleles. {W}e also measured the impact of exposure to permethrin on life-history traits to address the delayed efficacy of {ITN}s. {O}ur results showed that females that successfully blood-fed upon a permethrin-treated net were no longer inhibited by permethrin at the following exposure. {B}lood-meal inhibition due to permethrin was not affected by female size nor by exposure of mothers when testing the offspring, allowing to discard the effect of genetic or physiological selection. {B}esides, in our assays, exposure to permethrin did not affect mosquito fecundity, fertility nor survival. {T}hese results give insights to understand the long-term efficacy of {ITN}s, and allow to reevaluate the criteria used when choosing compounds for fighting malaria mosquitoes.},
  keywords = {},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {9},
  numero = {},
  pages = {art. 8177 [11 ]},
  ISSN = {2045-2322},
  year = {2019},
  DOI = {10.1038/s41598-019-44633-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076053},
}