@article{fdi:010075680,
  title = {{L}ow genetic diversity and complexity of submicroscopic {P}lasmodium falciparum infections among febrile patients in low transmission areas in {S}enegal},
  author = {{S}ane, {R}. and {T}alla, {C}. and {D}iouf, {B}. and {S}arr, {F}. {D}. and {D}iagne, {N}. and {F}aye, {J}. and {B}adiane, {A}. and {S}emb{\`e}ne, {P}. {M}. and {S}okhna, {C}heikh and {T}oure-{B}alde, {A}. and {N}iang, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {S}ubmicroscopic {P}lasmodium infections are common in malaria endemic countries, but very little studies have been done in {S}enegal. {T}his study investigates the genetic diversity and complexity of submicroscopic {P}. falciparum infections among febrile patients in low transmission areas in {S}enegal. {M}aterials and methods {H}undred and fifty blood samples were collected from febrile individuals living in {D}ielmo and {N}diop ({S}enegal) between {A}ugust 2014 and {J}anuary 2015, tested for microscopic and submicroscopic {P}. falciparum infections and characterized for their genetic diversity and complexity of infections using msp-1 and msp-2 genotyping. {R}esults {S}ubmicroscopic {P}. falciparum infections were 19.6% and 25% in {D}ielmo and {N}diop, respectively. {K}1 and 3{D}7 were the predominant msp-1 and msp-2 allelic types with respective frequencies of 67.36% and 67.10% in microscopic isolates and 58.24% and 78% in submicroscopic ones. {F}requencies of msp-1 allelic types were statistically comparable between the studied groups (p>0.05), and were respectively 93.54% vs 87.5% for {K}1, 60% vs 54.83% for {MAD}20 and 41.93% vs 22.5% for {RO}33 while frequencies of msp-2 allelic types were significantly highest in the microscopy group for {FC}27 (41.93% vs 10%, {F}isher's {E}xact {T}est, p = 0.001) and 3{D}7 (61.29% vs 32.5%, {F}isher's {E}xact {T}est, p = 0.02). {M}ultiplicities of infection were lowest in submicroscopic {P}. falciparum isolates. {C}onclusions {T}he study revealed a high submicroscopic {P}. falciparum carriage among patients in the study areas, and that submicroscopic {P}. falciparum isolates had a lower genetic diversity and complexity of malaria infections.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {14},
  numero = {4},
  pages = {e0215755 [14 p.]},
  ISSN = {1932-6203},
  year = {2019},
  DOI = {10.1371/journal.pone.0215755},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075680},
}