@article{fdi:010075644,
  title = {{A}ssociation mapping desiccation resistance within chromosomal inversions in the {A}frican malaria vector {A}nopheles gambiae},
  author = {{A}yala, {D}iego and {Z}hang, {S}. and {C}hateau, {M}. and {F}ouet, {C}. and {M}orlais, {I}sabelle and {C}ostantini, {C}arlo and {H}ahn, {M}. {W}. and {B}esansky, {N}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}nversion polymorphisms are responsible for many ecologically important phenotypes and are often found under balancing selection. {H}owever, the same features that ensure their large role in local adaptation-especially reduced recombination between alternate arrangements-mean that uncovering the precise loci within inversions that control these phenotypes is unachievable using standard mapping approaches. {H}ere, we take advantage of long-term balancing selection on a pair of inversions in the mosquito {A}nopheles gambiae to map desiccation tolerance via pool-{GWAS}. {T}wo polymorphic inversions on chromosome 2 of this species (denoted 2{L}a and 2{R}b) are associated with arid and hot conditions in {A}frica and are maintained in spatially and temporally heterogeneous environments. {A}fter measuring thousands of wild-caught individuals for survival under desiccation stress, we used phenotypically extreme individuals homozygous for alternative arrangements at the 2{L}a inversion to construct pools for whole-genome sequencing. {G}enomewide association mapping using these pools revealed dozens of significant {SNP}s within both 2{L}a and 2{R}b, many of which neighboured genes controlling ion channels or related functions. {O}ur results point to the promise of similar approaches in systems with inversions maintained by balancing selection and provide a list of candidate genes underlying the specific phenotypes controlled by the two inversions studied here.},
  keywords = {aridity tolerance ; balancing selection ; local adaptation ; recombination ; {CAMEROUN}},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {28},
  numero = {6},
  pages = {1333--1342},
  ISSN = {0962-1083},
  year = {2019},
  DOI = {10.1111/mec.14880},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075644},
}