Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Proceedings of the Royal Society B : Biological Sciences art. 20182178 [10 p.] West Nile Virus birds susceptibility reservoir competence index macroecology 2018 fdi:010075639 ENG Proceedings of the Royal Society B : Biological Sciences 0962-8452 ISI:000465428300010 1893 10.1098/rspb.2018.2178 https://www.documentation.ird.fr/hor/fdi:010075639 https://www.documentation.ird.fr/intranet/publi/2019/05/010075639.pdf 285 Horizon (IRD) Zoonotic diseases transmitted by wildlife affect biological conservation, public and animal health, and the economy. Current research efforts are aimed at finding wildlife pathogens at a given location. However, a meta-analytical approach may reveal emerging macroecological patterns in the host-pathogen relationship at different temporal and spatial scales. West Nile virus (WNV) is a pathogen with worldwide detrimental impacts on bird populations. To understand macroecological patterns driving WNV infection, we aimed to recognize unknown competent reservoirs using three disease metrics-serological prevalence (SP), molecular prevalence (MP) and mortality (M)-and test if these metrics are correlated with the evolutionary history, geographical origin of bird species, viral strain, time-space and methodology. We performed a quantitative review of field studies on birds sampled for WNV. We obtained 4945 observations of 949 species from 39 countries. Our analysis supported the idea that MP and M are good predictors of reservoir competence, and allowed us to identify potential competent reservoirs. Furthermore, results indicated that the variability of these metrics was attributable to phylogeny, time-space and sample size. A macroecological approach is needed to recognize susceptible species and competent reservoirs, and to identify other factors driving zoonotic diseases originating from wildlife. 052 ; 080 ; 020 UR209 / UR224 Mexique