@article{fdi:010075633,
  title = {{D}iversity of {T}oxoplasma gondii strains shaped by commensal communities of small mammals},
  author = {{G}alal, {L}. and {S}chares, {G}. and {S}tragier, {C}laire and {V}ignoles, {P}. and {B}rouat, {C}arine and {C}uny, {T}. and {D}ubois, {C}. and {R}ohart, {T}. and {G}lodas, {C}. and {D}arde, {M}. {L}. and {K}ane, {M}. and {N}iang, {Y}. and {D}iallo, {M}. and {S}ow, {A}. and {A}ubert, {D}. and {H}amidovic, {A}. and {A}jzenberg, {D}. and {M}ercier, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ommensal rodent species are key reservoirs for {T}oxoplasma gondii in the domestic environment. {I}n rodents, different {T}. gondii strains show variable patterns of virulence according to host species. {T}oxoplasma gondii strains causing non-lethal chronic infections in local hosts will be more likely to persist in a given environment, but few studies have addressed the possible role of these interactions in shaping the {T}. gondii population structure. {I}n addition, the absence of validated techniques for upstream detection of {T}. gondii chronic infection in wild rodents hinders exploration of this issue under natural conditions. {I}n this study, we took advantage of an extensive survey of commensal small mammals in three coastal localities of {S}enegal, with a species assemblage constituted of both native {A}frican species and invasive species. {W}e tested 828 individuals for {T}. gondii chronic infection using the modified agglutination test for antibody detection in serum samples and a quantitative {PCR} assay for detection of 7'. gondii {DNA} in brain samples. {T}he infecting 7'. gondii strains were genotyped whenever possible by the analysis of 15 microsatellite markers. {W}e found (i) a very poor concordance between molecular detection and serology in the invasive house mouse, (ii) significantly different levels of prevalence by species and (iii) the autochthonous {T}. gondii {A}frica 1 lineage strains, which are lethal for laboratory mice, only in the native {A}frican species of commensal small mammals. {O}verall, this study highlights the need to reconsider the use of {MAT} serology in natural populations of house mice and provides the first known data about {T}. gondii genetic diversity in invasive and native species of small mammals from {A}frica. {I}n light of these results, we discuss the role of invasive and native species, with their variable adaptations to different {T}. gondii strains, in shaping the spatial structure of 7'. gondii genetic diversity in {A}frica.},
  keywords = {{T}oxoplasma gondii ; {H}ammondia ; {N}eospora caninum ; {G}enetic diversity ; {R}odents ; {W}est {A}frica ; {SENEGAL} ; {AFRIQUE} {DE} {L}'{OUEST}},
  booktitle = {},
  journal = {{I}nternational {J}ournal for {P}arasitology},
  volume = {49},
  numero = {3-4},
  pages = {267--275},
  ISSN = {0020-7519},
  year = {2019},
  DOI = {10.1016/j.ijpara.2018.11.004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075633},
}