@article{fdi:010075515,
  title = {{A} {T}on{B}-dependent transporter is required for secretion of protease {P}op{C} across the bacterial outer membrane},
  author = {{G}omez-{S}antos, {N}. and {G}latter, {T}. and {K}oebnik, {R}alf and {S}wiatek-{P}olatynska, {M}. {A}. and {S}ogaard-{A}ndersen, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}on{B}-dependent transporters ({TBDT}s) are ubiquitous outer membrane beta-barrel proteins that import nutrients and bacteriocins across the outer membrane in a proton motive force-dependent manner, by directly connecting to the {E}xb{B}/{E}xb{D}/{T}on{B} system in the inner membrane. {H}ere, we show that the {TBDT} {O}ar in {M}yxococcus xanthus is required for secretion of a protein, protease {P}op{C}, to the extracellular milieu. {P}op{C} accumulates in the periplasm before secretion across the outer membrane, and the proton motive force has a role in secretion to the extracellular milieu. {R}econstitution experiments in {E}scherichia coli demonstrate that secretion of {P}op{C} across the outer membrane not only depends on {O}ar but also on the {E}xb{B}/{E}xb{D}/{T}on{B} system. {O}ur results indicate that {TBDT}s and the {E}xb{B}/{E}xb{D}/{T}on{B} system may have roles not only in import processes but also in secretion of proteins.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {10},
  numero = {},
  pages = {1360 [18 ]},
  ISSN = {2041-1723},
  year = {2019},
  DOI = {10.1038/s41467-019-09366-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075515},
}