Deletre E. auteur aut IRD Martin T. auteur aut IRD Dumenil C. auteur aut IRD Chandre Fabrice auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background Pyrethroid and organophosphate resistance in the malaria vector Anopheles gambiae has led to the search for not only alternative insecticides, but also repellent chemical compounds. However, little is known about the potential actions of repellents and the cross-resistance risk between insecticide and repellent compounds.Methods Here we show the action of permethrin, DEET, geraniol, carvacrol, culminaldehyde and cinnamaldehyde against three A. gambiae strains: Kis' (Kisumu susceptible strain), KdrKis' (pyrethroid resistant strain) and AcerKis' (organophosphate resistant strain), the last two differing from the first by a mutation on the kdr and ace1 genes, respectively. Conclusions Results from the DEET assays show it induced repellency for the resistant KdrKis and AcerKis strains but maintained irritancy for the susceptible strain. More generally, we show resistance genes modify the behavior of An. gambiae, increasing or decreasing the effectiveness of DEET and natural compounds, depending on the mutation. These findings offer a new avenue for research on the target and mechanism of repellent compounds. We discuss these findings in the context of vector control strategies. specialized Anopheles gambiae Permethrin Deterrent Mortality Geraniol Cinnamaldehyde 052 020 076 12 art. 89 [10 p.] 2019 1756-3305 https://www.documentation.ird.fr/hor/fdi:010075493 10.1186/s13071-019-3343-9 1756-3305 [F B010075493] https://www.documentation.ird.fr/hor/fdi:010075493 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-04/010075493.pdf IRD - Base Horizon / Pleins textes 2019-05-13 2025-02-24 fdi:010075493 fre