@article{fdi:010075493,
  title = {{I}nsecticide resistance modifies mosquito response to {DEET} and natural repellents},
  author = {{D}eletre, {E}. and {M}artin, {T}. and {D}umenil, {C}. and {C}handre, {F}abrice},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {P}yrethroid and organophosphate resistance in the malaria vector {A}nopheles gambiae has led to the search for not only alternative insecticides, but also repellent chemical compounds. {H}owever, little is known about the potential actions of repellents and the cross-resistance risk between insecticide and repellent compounds.{M}ethods {H}ere we show the action of permethrin, {DEET}, geraniol, carvacrol, culminaldehyde and cinnamaldehyde against three {A}. gambiae strains: {K}is' ({K}isumu susceptible strain), {K}dr{K}is' (pyrethroid resistant strain) and {A}cer{K}is' (organophosphate resistant strain), the last two differing from the first by a mutation on the kdr and ace1 genes, respectively. {C}onclusions {R}esults from the {DEET} assays show it induced repellency for the resistant {K}dr{K}is and {A}cer{K}is strains but maintained irritancy for the susceptible strain. {M}ore generally, we show resistance genes modify the behavior of {A}n. gambiae, increasing or decreasing the effectiveness of {DEET} and natural compounds, depending on the mutation. {T}hese findings offer a new avenue for research on the target and mechanism of repellent compounds. {W}e discuss these findings in the context of vector control strategies.},
  keywords = {{A}nopheles gambiae ; {P}ermethrin ; {D}eterrent ; {M}ortality ; {G}eraniol ; {C}innamaldehyde},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {12},
  numero = {},
  pages = {art. 89 [10 p.]},
  ISSN = {1756-3305},
  year = {2019},
  DOI = {10.1186/s13071-019-3343-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075493},
}