@article{fdi:010075313,
  title = {{N}eurymenolide {A}, a novel mitotic spindle poison from the {N}ew {C}aledonian {R}hodophyta {P}hacelocarpus neurymenioides},
  author = {{M}otuhi, {S}. {E}. and {F}eizbakhsh, {O}. and {F}oll-{J}osselin, {B}. and {B}aratte, {B}. and {D}elehouze, {C}. and {C}ousseau, {A}. and {F}ant, {X}. and {B}ulinski, {J}. {C}. and {P}ayri, {C}laude and {R}uchaud, {S}. and {M}ehiri, {M}. and {B}ach, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he marine -pyrone macrolide neurymenolide {A} was previously isolated from the {F}ijian red macroalga, {N}eurymenia fraxinifolia, and characterized as an antibacterial agent against antibiotic-resistant strains that also exhibited moderate cytotoxicity in vitro against cancer cell lines. {T}his compound was also shown to exhibit allelopathic effects on {S}cleractinian corals. {H}owever, to date no mechanism of action has been described in the literature. {T}he present study showed, for the first time, the isolation of neurymenolide {A} from the {N}ew {C}aledonian {R}hodophyta, {P}hacelocarpus neurymenioides. {W}e confirmed the compound's moderate cytotoxicity in vitro against several human cell lines, including solid and hematological malignancies. {F}urthermore, we combined fluorescence microscopy and flow cytometry to demonstrate that treatment of {U}-2 {OS} osteosarcoma human cells with neurymenolide {A} could block cell division in prometaphase by inhibiting the correct formation of the mitotic spindle, which induced a mitotic catastrophe that led to necrosis and apoptosis. {A}bsolute configuration of the stereogenic center {C}-17 of neurymenolide {A} was deduced by comparison of the experimental and theoretical circular dichroism spectra. {S}ince the total synthesis of this compound has already been described, our findings open new avenues in cancer treatment for this class of marine molecules, including a new source for the natural product.},
  keywords = {{N}ew {C}aledonia ; {P}hacelocarpus neurymenioides ; {R}hodophyta ; neurymenolide {A} ; mitotic spindle poison ; mitotic catastrophe ; necrosis ; apoptosis ; {NOUVELLE} {CALEDONIE}},
  booktitle = {},
  journal = {{M}arine {D}rugs},
  volume = {17},
  numero = {2},
  pages = {art. 93 [18 ]},
  ISSN = {1660-3397},
  year = {2019},
  DOI = {10.3390/md17020093},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075313},
}