@article{fdi:010075278,
  title = {{P}revalence of infection among asymptomatic and paucisymptomatic contact persons exposed to {E}bola virus in {G}uinea : a retrospective, cross-sectional observational study},
  author = {{D}iallo, {M}. {S}. {K}. and {R}abilloud, {M}. and {A}youba, {A}hidjo and {T}oure, {A}. and {T}haurignac, {G}uillaume and {K}eita, {A}.{K}. and {B}utel, {C}hristelle and {K}pamou, {C}. and {B}arry, {T}. {A}. and {S}all, {M}. {D}. and {C}amara, {I}. and {L}eroy, {S}. and {M}sellati, {P}hilippe and {E}cochard, {R}. and {P}eeters, {M}artine and {S}ow, {M}. {S}. and {D}elaporte, {E}. and {E}tard, {J}ean-{F}ran{\c{c}}ois and {T}averne, {B}ernard and {C}ontactebogui {S}tudy {G}roup,},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {T}he prevalence of {E}bola virus infection among people who have been in contact with patients with {E}bola virus disease remains unclear, but is essential to understand the dynamics of transmission. {T}his study aimed to identify risk factors for seropositivity and to estimate the prevalence of {E}bola virus infection in unvaccinated contact persons. {M}ethods {I}n this retrospective, cross-sectional observational study, we recruited individuals between {M}ay 12, 2016, and {S}ept 8, 2017, who had been in physical contact with a patient with {E}bola virus disease, from four medical centres in {G}uinea ({C}onakry, {M}acenta, {N}'zerekore, and {F}orecariah). {C}ontact persons had to be 7 years or older and not diagnosed with {E}bola virus disease. {P}articipants were selected through the {P}ostebogui survivors' cohort. {W}e collected self-reported information on exposure and occurrence of symptoms after exposure using a questionnaire, and tested antibody response against glycoprotein, nucleoprotein, and 40-k{D}a viral protein of {Z}aire {E}bola virus by taking a blood sample. {T}he prevalence of {E}bola virus infection was estimated with a latent class model. {F}indings 1721 contact persons were interviewed and given blood tests, 331 of whom reported a history of vaccination so were excluded, resulting in a study population of 1390. {S}ymptoms were reported by 216 (16%) contact persons. {T}he median age of participants was 26 years (range 7-88) and 682 (49%) were male. {S}eropositivity was identified in 18 (8.33%, 95% {CI} 5.01-12.80) of 216 paucisymptomatic contact persons and 39 (3.32%, 5.01-12.80) of 1174 (2-4) asymptomatic individuals (p=0.0021). {S}eropositivity increased with participation in burial rituals (adjusted odds ratio [a{OR}] 2.30, 95% {CI} 1.21-4.17; p=0.0079) and exposure to blood or vomit (a{OR} 2.15, 1.23-3.91; p=0.0090). {F}requency of {E}bola virus infection varied from 3.06% (95% {CI} 1.84-5.05) in asymptomatic contact persons who did not participate in burial rituals to 5.98% (2.81-8.18) in those who did, and from 7.17% (3.94-9.09) in paucisymptomatic contact persons who did not participate in burial rituals to 17.16% (12.42-22.31) among those who did. {I}nterpretation {T}his study provides a new assessment of the prevalence of {E}bola virus infection among contact persons according to exposure, provides evidence for the occurrence of paucisymptomatic cases, and reinforces the importance of closely monitoring at-risk contact persons.},
  keywords = {{GUINEE}},
  booktitle = {},
  journal = {{L}ancet {I}nfectious {D}iseases},
  volume = {19},
  numero = {3},
  pages = {308--316},
  ISSN = {1473-3099},
  year = {2019},
  DOI = {10.1016/s1473-3099(18)30649-2},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075278},
}